EMAIL THIS PAGE TO A FRIEND

The Journal of biological chemistry

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.


PMID 6273400

Abstract

Arachidonate stimulates the production of large quantities of superoxide by human neutrophils: 93.8 +/- 12.5 S.D. nmol of O2(-)/min/10(7) cells. This rate is comparable to that observed with the most effective neutrophil-stimulating agents previously reported. Other cis-unsaturated fatty acids are also capable of eliciting this response, the order of effectiveness being: arachidonate greater than gamma-linolenate greater than linoleate greater than oleate. Linolelaidate, myristate, and palmitate are ineffective. These data are discussed in relation to recent reports concerning the oxidation of arachidonic acid by human neutrophils and by a cell-free system that generates superoxide and hydrogen peroxide.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SML1395
Arachidonic acid sodium salt from Mortierella alpina, ≥98.5% (GC)
C20H31O2Na