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Science (New York, N.Y.)

Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog.


PMID 7001627

Abstract

An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.

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17816
N-Fmoc-Freidinger’s lactam, ≥95.0% (HPLC)
C24H26N2O5