EMAIL THIS PAGE TO A FRIEND

International pharmacopsychiatry

Amoxapine: a review of literature.


PMID 7016801

Abstract

Amoxapine, a new antidepressant, is a tricyclic debenzoxazepine compound, the demethylated metabolite of the neuroleptic loxapine. In animal pharmacological studies, amoxapine has shown striking similarities to imipramine. In contrast to the prototype antidepressant drug, however, amoxapine does not interact with serotonin. In 10 uncontrolled clinical trials amoxapine was shown to have antidepressant effects in the dosage range of 100-300 mg/day. This was verified in 10 published standard, and placebo and standard controlled clinical studies in which amoxapine was superior to placebo and equal in overall therapeutic efficacy to imipramine and amitriptyline. Side effects were similar to the reference drugs.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

A129
Amoxapine
C17H16ClN3O