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Nutrition reviews

Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin.


PMID 8090377

Abstract

Fumonisins, mycotoxins found on corn and other grains, can act as carcinogens. Recent studies have shown that fumonisin B1 stimulates cell proliferation due to inhibition of sphinganine N-acyl-transferase, an important rate limiting enzymatic step in sphingolipid biosynthesis. Subsequent accumulation of free sphingoid bases in the cell can act as tumor promoters.

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