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Pharmacological research

Separation of DL-dopa by means of micellar electrokinetic capillary chromatography after derivatization with Marfey's reagent.


PMID 9356208

Abstract

Micellar electrokinetic capillary chromatography was used to separate levodopa (L-3,4-dihydroxyphenyl-L-alanine), dextrodopa (D-3,4-dihydroxyphenyl-L-alanine) and DL-3-O-methyl-dopa, a metabolite of dopa, which were derivatised with the Marfey's reagent, in sodium borate, sodium dodecyl sulfate and acetonitile buffer system. Whereas DL-dopa derivatives could be separated, DL-3-O-methyl-dopa derivatives could not.

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D9503
3,4-Dihydroxy-DL-phenylalanine
C9H11NO4