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Structure (London, England : 1993)

Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors.


PMID 9438871

Abstract

Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.