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159220 Aldrich

Diethyl pyrocarbonate

97%

Synonym: DEP, DEPC, Diethyl dicarbonate, Diethyl oxydiformate, Ethoxyformic acid anhydride

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Properties

Related Categories Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis,
assay   97%
refractive index   n20/D 1.398(lit.)
bp   93-94 °C/18 mmHg(lit.)
density   1.101 g/mL at 25 °C(lit.)
storage temp.   2-8°C

Description

Application

Modification reagent for His and Tyr residues in proteins. Robust probe for structural disruptions in dsDNA, reacting with fully or partially unstacked bases.

Diethyl pyrocarbonate was used as:
• nuclease inhibitor for the extraction of undegraded nucleic acids from etiolated and green plant tissues
• an antimicrobial additive
• ribonuclease inhibitor
• histidine residue modifier
• reagent for conversion of imines to carbamates

Biochem/physiol Actions

Inactivates RNase in solution at about 0.1% (v/v), thus protecting RNA against degradation.

Packaging

25, 100 g in poly bottle

5 g in glass bottle

General description

Diethyl pyrocarbonate reacts selectively with the single-stranded loops of cruciform structures. The irreversible inactivation of ribonuclease with diethylpyrocarbonate has been studied.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
3
RTECS 
LQ9350000
Flash Point(F) 
156.2 °F
Flash Point(C) 
69 °C
Protocols & Articles

Articles

Complex Hydrides: A New Category of Solid-state Lithium Fast-ion Conductors

Research and development of solid-state lithium fast-ion conductors is crucial because they can be potentially used as solid electrolytes in all-solid-state batteries, which may solve the safety and ...
Motoaki Matsuo,1 Hiroyuki Oguchi,1,2 Hideki Maekawa,2 Hitoshi Takamura,2Shin-ichi Orimo,1*
Material Matters Volume 5 Article 4
Keywords: Calorimetry, Deposition, Diffraction, Diffusion, Melting, Nuclear magnetic resonance spectroscopy, Raman spectroscopy, Search, Spectra, Spectroscopy, Substitutions, Support, X-Ray diffraction, transformation

Peer-Reviewed Papers
15

References

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