159220 Aldrich

Diethyl pyrocarbonate


Synonym: DEP, DEPC, Diethyl dicarbonate, Diethyl oxydiformate, Ethoxyformic acid anhydride


Related Categories Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis,
assay   97%
refractive index   n20/D 1.398(lit.)
bp   93-94 °C/18 mmHg(lit.)
density   1.101 g/mL at 25 °C(lit.)
storage temp.   2-8°C



Modification reagent for His and Tyr residues in proteins. Robust probe for structural disruptions in dsDNA, reacting with fully or partially unstacked bases.1

Utilized as an antimicrobial additive, a ribonuclease inhibitor, a histidine residue modifier, and as a reagent for conversion of imines to carbamates.

Biochem/physiol Actions

Inactivates RNase in solution at about 0.1% (v/v), thus protecting RNA against degradation.


25, 100 g in poly bottle

5 g in glass bottle

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