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693316 - (S)-2-[[3,5-Bis(trifluoromethyl)phenyl]thioureido]-N-benzyl-N,3,3-trimethylbutanamide

693316 Aldrich

(S)-2-[[3,5-Bis(trifluoromethyl)phenyl]thioureido]-N-benzyl-N,3,3-trimethylbutanamide

97%

Synonym: (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-3,3-trimethyl-N-(phenylmethyl)butanamide

CAS Number 959979-30-7
Empirical Formula (Hill Notation) C₂₃H₂₅F₆N₃OS
Molecular Weight 505.52
MDL number MFCD10567031
Popular Documents: Specification Sheet (PDF)

(S)-2-[[3,5-Bis(trifluoromethyl)phenyl]thioureido]-N-benzyl-N,3,3-trimethylbutanamide 97%

Properties

Related Categories	Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Jacobsen Thioureas
assay	97%
optical activity	[α]20/D -57.0°, c = 1 in chloroform
mp	147-152 °C

Description

Application

Versatile catalyst for reactions including the Mannich reaction.¹

Packaging

100, 500 mg in glass bottle

Protocols & Applications

Asymmetric Strecker Reactions using Jacobsen Thioureas

Price and Availability

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(2<I>S</I>)<WBR>-<WBR>3,3-<WBR>Dimethyl-<WBR>2-<WBR>[[(1<I>R</I>,2<I>R</I>)<WBR>-<WBR>2-<WBR>(2-<WBR>methyl-<WBR>5-<WBR>phenyl-<WBR>1-<WBR>pyrrolyl)<WBR>cyclohexyl]<WBR>thioureido]<WBR>-<I>N</I>,<I>N</I>-<WBR>bis(2-<WBR>isobutyl)<WBR>butanamide

693340(2S)-3,3-Dimethyl-2-[[(1R,2R)-2-(2-methyl-5-phenyl-1-pyrrolyl)cyclohexyl]thioureido]-N,N-bis(2-isobutyl)butanamide

97%

(<I>R</I>)-<I>N</I>-[(1<I>R</I>,2<I>R</I>)<WBR>-<WBR>2-<WBR>(3-<WBR>(3,5-<WBR>Bis(trifluoromethyl)<WBR>phenyl)<WBR>ureido)<WBR>cyclohexyl]<WBR>-<I>tert</I>-butyl-sulfinamide

699918(R)-N-[(1R,2R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)ureido)cyclohexyl]-tert-butyl-sulfinamide

96%

(<I>S</I>)-2-[[(1<I>R</I>,2<I>R</I>)<WBR>-<WBR>2-<WBR>Aminocyclohexyl]<WBR>thioureido]<WBR>-<I>N</I>-benzyl-<I>N</I>,3,3-<WBR>trimethylbutanamide

693413(S)-2-[[(1R,2R)-2-Aminocyclohexyl]thioureido]-N-benzyl-N,3,3-trimethylbutanamide

95%

(<I>S</I>)-2-[3-[(1<I>R</I>,2<I>R</I>)<WBR>-<WBR>2-<WBR>(Dipropylamino)<WBR>cyclohexyl]<WBR>thioureido]<WBR>-<I>N</I>-<WBR>isopropyl-<WBR>3,3-<WBR>dimethylbutanamide

693464(S)-2-[3-[(1R,2R)-2-(Dipropylamino)cyclohexyl]thioureido]-N-isopropyl-3,3-dimethylbutanamide

95%

3-[(<I>E</I>)-[[(1<I>R</I>,2<I>R</I>)-2-[[(1<I>S</I>)<WBR>-<WBR>1-<WBR>[(Dimethylamino)<WBR>carbonyl]<WBR>-<WBR>2,2-<WBR>dimethylpropyl]<WBR>thioureido]<WBR>cyclohexyl]<WBR>imino]<WBR>methyl]<WBR>-<WBR>5-<WBR>(<I>tert</I>-<WBR>butyl)<WBR>-<WBR>4-<WBR>hydroxyphenyl pivalate

6934213-[(E)-[[(1R,2R)-2-[[(1S)-1-[(Dimethylamino)carbonyl]-2,2-dimethylpropyl]thioureido]cyclohexyl]imino]methyl]-5-(tert-butyl)-4-hydroxyphenyl pivalate

95%

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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1. Divergent Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines Wenzel, A.G.; Lalonde, M.P.; Jacobsen, E.N. Synlett, 1919, (2003)

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Symbol	GHS07
Signal word	Warning
Hazard statements	H302-H312-H315-H319-H335-H413
Precautionary statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes (Europe)	Xn
Risk Statements (Europe)	20/21/22-36/37/38
Safety Statements (Europe)	26-36/37
WGK Germany	3

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