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D26202 Aldrich

3,5-Diamino-1,2,4-triazole

98%

Synonym: Guanazole

Purchase

Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Triazoles
assay   98%
mp   202-205 °C(lit.)

Description

Application

Inhibitor of DNA synthesis.

Packaging

25, 100 g in poly bottle

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
36/37
WGK Germany 
3
RTECS 
XZ4535000

Protocols & Articles

Peer-Reviewed Papers

References

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Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues. Larsen IK, Sjöberg BM, and Thelander L Eur. J. Biochem. 125(1), 75-81, (1982)

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Current investigational drugs of interest in the Chemotherapy Program of the National Cancer Institute. Carter SK and Slavik M Natl. Cancer Inst. Monogr. (45), 101-21, (1977)

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Synthesis and evaluation of guanazole prodrugs as antineoplastic agents. Dias Selassie C, Lien EJ, and Khwaja TA J. Pharm. Sci. 70(11), 1281-3, (1981)

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Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy. Cory JG, Sato A, and Lasater L Adv. Enzyme Regul. 19, 139-50, (1980)

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Studies of mammalian ribonucleotide reductase activity in intact permeabilized cells: a genetic approach. Wright JA, Hards RG, and Dick JE Adv. Enzyme Regul. 19, 105-27, (1980)

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Ribonucleotide reductase from wild type and hydroxyurea-resistant chinese hamster ovary cells. Lewis WH and Wright JA J. Cell Physiol. 97(1), 87-97, (1978)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY). Moore EC and Hurlbert RB Pharmacol. Ther. 27(2), 167-96, (1985)

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Effect of iron-chelating agents on inhibitors of ribonucleotide reductase. Cory JG, Lasater L, and Sato A Biochem. Pharmacol. 30(9), 979-84, (1981)

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N-carbamoyloxyurea-resistant Chinese hamster ovary cells with elevated levels of ribonucleotide reductase activity. Hards RG and Wright JA J. Cell Physiol. 106(2), 309-19, (1981)

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DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin. Suter W and Romagna F Mutat. Res. 231(2), 251-64, (1990)

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Inhibition of ribonucleotide reductases encoded by herpes simplex viruses. Spector T Pharmacol. Ther. 31(3), 295-302, (1985)

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A series of N-carbamoyloxyurea resistant cell lines with alterations in ribonucleotide reductase: lack of coordination in pyrimidine and purine reductase activity. Hards RG and Wright JA Can. J. Biochem. Cell Biol. 61(2-3), 120-9, (1983)

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Measurements of ionization constants and partition coefficients of quanazole prodrugs. Alhaider AA, Selassie CD, Chua SO, et al. J. Pharm. Sci. 71(1), 89-94, (1982)

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Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit. Sato A, Bacon PE, and Cory JG Adv. Enzyme Regul. 22, 231-41, (1984)

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Molecular geometry and vibrational studies of 3,5-diamino-1,2,4-triazole using quantum chemical calculations and FT-IR and FT-Raman spectroscopies. Guennoun L, El jastimi J, Guédira F, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(1), 347-53, (2011)

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Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure. Tipples G and McClarty G J. Bacteriol. 173(16), 4932-40, (1991)

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Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia. Gale GR, Atkins LM, Meischen SJ, et al. Cancer Treat. Rep. 63(3), 449-56, (1979)

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Herpes simplex type 1 ribonucleotide reductase. Mechanism studies with inhibitors. Spector T and Jones TE J. Biol. Chem. 260(15), 8694-7, (1985)

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[Pharmacokinetics of antitumor drugs]. Filov VA and Kulik GI Vopr. Onkol. 29(7), 3-13, (1983)

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Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides. Kolb VM, Dworkin JP, and Miller SL J. Mol. Evol. 38, 549-57, (1994)

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Guanazole in the treatment of advanced bronchogenic carcinoma: a pilot study of the Southeastern Cancer Study Group. Krauss S, Broder LE, and Birch R Cancer Treat. Rep. 70(7), 913-4, (1986)

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Studies on the selective toxicity of guanazole in mice. Dave C, Paul MA, and Rustum YM Eur. J. Cancer 14(1), 33-40, (1978)

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Evolution of bacterial genomes. Trevors JT Antonie van Leeuwenhoek 71(3), 265-70, (1997)

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Molecular structure and vibrational study of diprotonated guanazolium using DFT calculations and FT-IR and FT-Raman spectroscopies. Guennoun L, Zaydoun S, El Jastimi J, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97, 975-85, (2012)

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Drug-induced loss of unstably amplified genes. Wani MA and Snapka RM Cancer Invest. 8(6), 587-93, (1990)

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Beil. 26,IV,1161

Corp MSDS 1, 1060:C / FT-IR 2 (3), 3527:C / FT-IR 1 (2), 627:D / IR-Spectra (3), 1225:E / IR-Spectra (2), 1066:F / RegBook 1 (2), 2367:I / Sax 6, 891 / Sigma FT-IR 1 (2), 434:A / Structure Index 1, 375:B:6

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