Organomagnesium Methods In Organic Synthesis

General description

The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects as well as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds.

Table of Contents

Introduction and General References.
General Considerations in the Application of Organomagnesium Compounds in Organic and Organometallic Synthesis.
Preparation of Organomagnesium Compounds.
Addition of Organomagnesium Compounds to Carbon-Carbon Multiple Bonds.
Addition of Organomagnesium Compounds to Carbon-Nitrogen Multiple Bonds.
Addition of Organomagnesium Compounds to Carbonyl Groups.
Carbophilic Addition of Organomagnesium Compounds to Thiocarbonyl Groups.
Substitution at Carbon by Organomagnesium Compounds.
Carbenoid and Arynoid Reactions of Organomagnesium Compounds.
Reactions of Organomagnesium Compounds with Proton Donors.
Formation of Carbon-Nitrogen Bonds via Organomagnesium Compounds.
Formation of Carbon-Oxygen Bonds via Organomagnesium Compounds.
Formation of Carbon-Sulfur, Carbon-Selenium, and Carbon-Tellurium Bonds via Organomagnesium Compounds.
Formation of Carbon-Halogen Bonds via Organomagnesium Compounds.
Synthesis of Organoboron, Organosilicon, and Organophosphorous Compounds from Organomagnesium Compounds.
Organomagnesium Compounds in the Synthesis of Other Organometallic Compounds.
Index of Compounds and Methods.