Phenobarbital

Papers

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design. Perumal Yogeeswari et al J. Med. Chem. 48, 6202-11, (2005)

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Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines. Zhi-Feng Xie et al Bioorg. Med. Chem. Lett. 15, 4803-5, (2005)

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Psychopharmacological profile of the alkaloid psychollatine as a 5HT2A/C serotonin modulator. Fernanda L Both et al J. Nat. Prod. 68, 374-80, (2005)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones. Hardik J Patel et al Bioorg. Med. Chem. Lett. 16, 4644-7, (2006)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach. Perumal Yogeeswari et al Bioorg. Med. Chem. Lett. 17, 3712-5, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. Kamelia M Amin et al Bioorg. Med. Chem. 16, 5377-88, (2008)

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Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives. Pierre Morieux et al Bioorg. Med. Chem. 16, 8968-75, (2008)

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Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation. Alessio Coi et al Eur. J. Med. Chem. 43, 2479-88, (2008)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors. David J Johnson et al Antimicrob. Agents Chemother. 52, 1438-45, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxic. Mech. Methods 18, 217-27, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. Ki Duk Park et al J. Med. Chem. 52, 6897-911, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants. Faizul Azam et al Eur. J. Med. Chem. 44, 203-11, (2009)

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Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea. Sushil K Kashaw et al Eur. J. Med. Chem. 44, 4335-43, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides. Christophe Salomé et al J. Med. Chem. 53, 1288-305, (2010)

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Merging the Structural Motifs of Functionalized Amino Acids and α-Amino amides: Compounds with Significant Anticonvulsant Activities Salome, C.; et al. J. Med. Chem. 53, 3756-3771, (2010)

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The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. Pierre Morieux et al J. Med. Chem. 53, 5716-26, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening. Nadeem Siddiqui et al Eur. J. Med. Chem. 45, 1536-43, (2010)

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Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine. Li-Ping Guan et al Eur. J. Med. Chem. 45, 1746-52, (2010)

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Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives. Ozair Alam et al Eur. J. Med. Chem. 45, 2467-72, (2010)

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Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. Xianran He et al Eur. J. Med. Chem. 45, 5870-7, (2010)

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SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Sam Hopkins et al Antimicrob. Agents Chemother. 54, 660-72, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Amber M King et al J. Med. Chem. 54, 6417-31, (2011)

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Defining the Structural Parameters That Confer Anticonvulsant Activity by the Site-by-Site Modification of (R)-N'-Benzyl 2-Amino-3-methylbutanamide A. M. King, et al., J. Med. Chem. 54, 6432-6442, (2011)

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Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Xian-Qing Deng et al Eur. J. Med. Chem. 46, 2955-63, (2011)

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Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines. Maciej Dawidowski et al Eur. J. Med. Chem. 46, 4859-69, (2011)

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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Holger Fischer et al J. Med. Chem. 55, 126-39, (2012)

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Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones. Xianran He et al Eur. J. Med. Chem. 48, 338-46, (2012)

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Merck 14,7238

Beil. 24,IV,2081