Technical information & documentation associated with this product is available in the
Safety & Documentation tab.
Articles
Indoles
Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Building blocks, Cardiovascular, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory
Related Content
Indoles, Purines, and Their Isosteres
Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry
Papers
Set your institution to view full text papers.
1. Fluorescent carbazolylurea- and carbazolylthiourea-based anion receptors and sensors Hiscock, J. R.; et al. Supramol. Chem. 22, 647, (2010)
2. Acyclic indole and carbazole-based sulfate receptors Gale, P. A.; et al. Chem. Sci. 1, 215, (2010)
3. Optimization of 5-phenyl-3-pyridinecarbonitriles as PKC? inhibitors Boschelli, D. H.; et al. Bioorg. Med. Chem. Lett. 19, 3623, (2009)
Loading...
4. Design, structure-activity relationships, X-ray crystal structure, and energetic contributions of a critical P1 pharmacophore: 3-chloroindole-7-yl-based factor Xa inhibitors. Shi, Y.; et al. J. Med. Chem. 51, 7541, (2008)
Loading...
5. Discovery of a potent and selective Aurora kinase inhibitor Oslob, J. D.; et al. Bioorg. Med. Chem. Lett. 18, 4880, (2008)
Loading...
6. (S)-N-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor Bell, M. G.; et al. J. Med. Chem. 50, 6443, (2007)
Loading...
7. Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors Price, S.; et al. Bioorg. Med. Chem. Lett. 17, 370, (2007)
Loading...
8. Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists Drizin, I.; et al. Bioorg. Med. Chem. 14, 4740, (2006)
Loading...
9. A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors Owa, T.; et al. Bioorg. Med. Chem. Lett. 10, 1223, (2000)
Loading...