|Related Categories||Analytical Reagents, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics T-Z,|
|mp||234-237 °C (dec.)(lit.)|
|234-237 °C (dec.)|
|solubility||methanol: ≤ 10 TE CF0.1 g/mL|
Thiomersal is an organomercury compound that is used as an antiseptic and antifungal agent It is used as a vaccine preservative. During cell culture, thiomersal is used to prevent overgrowth in fibroblast cells 1. It has been used to preserve Atovaquone 2.
Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.
Certificate of Analysis
|Symbol||GHS06, GHS08, GHS09|
|Precautionary statements||P260-P264-P273-P280-P284-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+,N|
|Risk Statements (Europe)||26/27/28-33-50/53|
|Safety Statements (Europe)||13-28-36-45-60-61|
|RIDADR||UN 2025 6.1 / PGIII|
|Flash Point(F)||482 °F|
|Flash Point(C)||250 °C|
2. Atovaquone Maintenance Therapy Prevents Reactivation of Toxoplasmic Encephalitis in a Murine Model of Reactivated Toxoplasmosis. Ildiko R. Dunay, Markus M. Heimesaat, et al. Antimicrob. Agents Chemother. 48, 4848-4854, (2004)
Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain. Khan SA, Rossi AM, Riley AM, et al. Biochem. J. 451(2), 177-84, (2013)
[Immune reactions of palatine tonsils in the patients with chronic tonsillitis and the possibilities for their immunological rehabilitation with the use of imudon]. Aznabaeva LF, Aref'eva NA, and Gumerova MI Vestn. Otorinolaringol. (6), 67-70, (2012)
Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats. Khan A, Sulkowski ZL, Chen T, et al. J. Physiol. Pharmacol. 63(3), 277-83, (2012)
Cytoprotective effect of hyaluronic acid and hydroxypropyl methylcellulose against DNA damage induced by thimerosal in Chang conjunctival cells. Ye J, Zhang H, Wu H, et al. Graefes Arch. Clin. Exp. Ophthalmol. 250(10), 1459-66, (2012)
Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: implications for association with developmental disorders. Ida-Eto M, Oyabu A, Ohkawara T, et al. Brain Dev. 35(3), 261-4, (2013)
Effect of duration of breastfeeding on neuropsychological development at 10 to 12 years of age in a cohort of healthy children. Tozzi AE, Bisiacchi P, Tarantino V, et al. Dev. Med. Child Neurol. 54(9), 843-8, (2012)
Mercury disposition in suckling rats: comparative assessment following parenteral exposure to thiomersal and mercuric chloride. Blanuša M, Orct T, Vihnanek Lazarus M, et al. J. Biomed. Biotechnol. 2012, 256965, (2012)
Metronidazole thiosalicylate conjugates: synthesis, crystal structure, docking studies and antiamoebic activity. Salahuddin A, Agarwal SM, Avecilla F, et al. Bioorg. Med. Chem. Lett. 22(17), 5694-9, (2012)
ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3. Yeter D and Deth R Autoimmun. Rev. 11(12), 903-8, (2012)
Pitfalls in anti-influenza T cell detection by Elispot using thimerosal containing pandemic H1N1 vaccine as antigen. Chauvat A, Benhamouda N, Loison E, et al. J. Immunol. Methods 378(1-2), 81-7, (2012)
Aldrich MSDS 1, 919:D / Corp MSDS 1 (1), 1633:C / FT-IR 2 (2), 2783:D / FT-IR 1 (2), 273:D / IR-Spectra (3), 1014:A / IR-Spectra (2), 887:G / RegBook 1 (2), 1865:D / Sax 6, 1756 / Sigma FT-IR 1 (1), 722:A / Structure Index 1, 299:B:4
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