|Related Categories||Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology,|
human ... ESR1(2099)|
rat ... Esr1(24890)
The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.
Reduced analogue of diethylstilbestrol.
1, 5 g in poly bottle
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P201-P308 + P313|
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||45|
|Safety Statements (Europe)||53-45|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat. Thompson KL, Haskins K, Rosenzweig BA, et al. Int. J. Toxicol. 31(1), 14-24, (2012)
Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Xu Q, Wang M, Yu S, et al. Analyst 136(23), 5030-7, (2011)
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. Dhagat U, Endo S, Mamiya H, et al. Acta Crystallogr. D, Biol. Crystallogr. 65(Pt 3), 257-65, (2009)
Comparison of time-resolved fluoroimmunoassay for determining hexoestrol residues in chicken muscle tissues based on polyclonal antibodies with liquid chromatography and tandem mass spectrometry. Xiangqian L, Yongming H, Tieming H, et al. Ann. Chim. 97(3-4), 177-86, (2007)
Determination of hexoestrol residues in animal tissues based on enzyme-linked immunosorbent assay and comparison with liquid chromatography-tandem mass spectrometry. Xu C, Peng C, Liu L, et al. J. Pharm. Biomed. Anal. 41(3), 1029-36, (2006)
Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3',4'-quinone or enzyme-activated 3'-hydroxyhexestrol. Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens. Saeed M, Gunselman SJ, Higginbotham S, et al. Steroids 70(1), 37-45, (2005)
Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry. Dickson LC, MacNeil JD, Reid J, et al. J. AOAC Int. 86(4), 631-9, (2003)
Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins. Logie C, Nichols M, Myles K, et al. Mol. Endocrinol. 12(8), 1120-32, (1998)
Dynamic liquid-liquid-solid microextraction based on molecularly imprinted polymer filaments on-line coupling to high performance liquid chromatography for direct analysis of estrogens in complex samples. Zhong Q, Hu Y, Hu Y, et al. J. Chromatogr. A 1241, 13-20, (2012)
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation. Robin MA, Descatoire V, Pessayre D, et al. Toxicol. In Vitro 22(6), 1511-9, (2008)
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