414220 Sigma-Aldrich

Propylene carbonate

CHROMASOLV®, for HPLC, 99.7%

Synonym: 1,2-Propanediol cyclic carbonate, 4-Methyl-1,3-dioxolan-2-one

  • CAS Number 108-32-7

  • Empirical Formula (Hill Notation) C4H6O3

  • Molecular Weight 102.09

  •  Beilstein Registry Number 107913

  •  EC Number 203-572-1

  •  MDL number MFCD00005385

  •  PubChem Substance ID 24865903



Related Categories Alternative Energy, Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, CHROMASOLV for HPLC,
  for HPLC
vapor pressure   0.13 mmHg ( 20 °C)
  0.98 mmHg ( 50 °C)
assay   99.7%
autoignition temp.   851 °F
expl. lim.   14.3 %
impurities   <0.020% water
evapn. residue   <0.0005%
refractive index   n20/D 1.421(lit.)
bp   240 °C(lit.)
mp   −55 °C(lit.)
density   1.204 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 235 nm Amax: 1.00
  λ: 280 nm Amax: 0.50
  λ: 300 nm Amax: 0.30
  λ: 350 nm Amax: 0.05
  λ: 375-400 nm Amax: 0.01


Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.


1, 2 L in glass bottle

General description

Propylene carbonate is a cyclic carbonate1 commonly used as an organic solvent. Many methods have been reported for its synthesis from propylene oxide and carbon dioxide under different reaction conditions.2,3,4 The dielectric property, relaxation times and viscosity has been studied.1 It is a potential electrochemical solvent in preparing aprotic battery electrolytes.5

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Poly(propylene carbonate)

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ReagentPlus®, 99%

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
WGK Germany 
Flash Point(F) 
240.8 °F
Flash Point(C) 
116 °C
Protocols & Articles


Complex Hydrides: A New Category of Solid-state Lithium Fast-ion Conductors

Research and development of solid-state lithium fast-ion conductors is crucial because they can be potentially used as solid electrolytes in all-solid-state batteries, which may solve the safety and ...
Motoaki Matsuo,1 Hiroyuki Oguchi,1,2 Hideki Maekawa,2 Hitoshi Takamura,2Shin-ichi Orimo,1*
Material Matters Volume 5 Article 4
Keywords: Calorimetry, Deposition, Diffraction, Diffusion, Melting, Nuclear magnetic resonance spectroscopy, Raman spectroscopy, Search, Spectra, Spectroscopy, Substitutions, Support, X-Ray diffraction, transformation

Determination of Water Content in Propylene Carbonate Using Karl Fischer Titration

Water determination in hydrocarbons is relatively straightforward. Lower hydrocarbons dissolve in methanol, however, even if the dissolution is incomplete, the water is rapidly extracted and complete...
Keywords: Pharmaceutical, Solvents, Titrations

Peer-Reviewed Papers


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1. Dielectric properties and relaxation in ethylene carbonate and propylene carbonate. Payne R and Theodorou IE. J. Phys. Chem. 76(20), 2892-2900, (1972)

2. A rapid and effective synthesis of propylene carbonate using a supercritical CO2-ionic liquid system. Kawanami H, et al. Chem. Commun. (Camb.) 7, 896-897, (2003)

3. Organic solvent-free process for the synthesis of propylene carbonate from supercritical carbon dioxide and propylene oxide catalyzed by insoluble ion exchange resins. Y, et al. Green Chem. 7(7), 518-523, (2005)

4. New procedure for recycling homogeneous catalyst: propylene carbonate synthesis under supercritical CO2 conditions. He LN, et al. Green Chem. 5(1), 92-94, (2003)

5. Analysis and distillation of propylene carbonate. Jasinski RJ and Kirkland S. Anal. Chem. 39(13), 1663-1665, (1967)

Exfoliation of graphite oxide in propylene carbonate and thermal reduction of the resulting graphene oxide platelets. Zhu Y, et al. ACS Nano 4(2), 1227-1233, (2010)

Kühnel I, et al. Holzforschung 69(5), 531-538, (2015)

Propylene carbonate as a solvent for asymmetric hydrogenations. Bayardon J, et al. Angew. Chem. Int. Ed. Engl. 46(31), 5971-5974, (2007)

Synthesis of finely divided molybdenum sulfide nanoparticles in propylene carbonate solution. Afanasiev P. J. Solid State Chem. 213, 158-164, (2014)

Determination of solubility parameters of ionic liquids and ionic liquid/solvent mixtures from intrinsic viscosity. Weerachanchai P, Wong Y, Lim KH, et al. ChemPhysChem 15(16), 3580-91, (2014)


In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623. McEvoy CL, Trevaskis NL, Edwards GA, et al. Eur. J. Pharm. Biopharm. 88(3), 973-85, (2014)


On prilling of hydrophilic microgels in lipid dispersions using mono-N-carboxymethyl chitosan for oral biologicals delivery. De Kruif JK, Fasler-Kan E, Varum F, et al. J. Pharm. Sci. 103(11), 3675-87, (2014)


Electron paramagnetic resonance imaging for real-time monitoring of Li-ion batteries. Sathiya M, Leriche JB, Salager E, et al. Nat. Commun. 6, 6276, (2015)


Comparative percutaneous permeation study using caffeine-loaded microemulsion showing low reliability of the frozen/thawed skin models. Sintov AC, Greenberg I, et al. Int. J. Pharm. 471(1-2), 516-24, (2014)


Improvement of efficiency in the enzymatic synthesis of lactulose palmitate. Bernal C, Illanes A, Wilson L, et al. J. Agric. Food Chem. 63(14), 3716-24, (2015)


High rate and stable cycling of lithium metal anode. Qian J, Henderson WA, Xu W, et al. Nat. Commun. 6, 6362, (2015)


Transdermal delivery of curcumin via microemulsion. Sintov AC Int. J. Pharm. 481(1-2), 97-103, (2015)


Characterization of a riboflavin non-aqueous nanosuspension prepared by bead milling for cutaneous application. Sato T, Takeuchi H, Sakurai T, et al. Chem. Pharm. Bull. 63(2), 88-94, (2015)


Preparation of flexible and elastic poly(trimethylene carbonate) structures by stereolithography. Schüller-Ravoo S, Feijen J, and Grijpma DW Macromol. Biosci. 11(12), 1662-71, (2011)


Ionic liquid-nanoparticle hybrid electrolytes and their application in secondary lithium-metal batteries. Lu Y, Das SK, Moganty SS, et al. Adv. Mater. 24(32), 4430-5, (2012)


[Influence of aligned electrospinning poly (propylene carbonate) on axonal growth of dorsal root ganglion in vitro]. Zhao Z, Wang Y, Peng J, et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25(2), 171-5, (2011)


Mussel-inspired polydopamine-treated polyethylene separators for high-power li-ion batteries. Ryou MH, Lee YM, Park JK, et al. Adv. Mater. 23(27), 3066-70, (2011)


Models for liquid-liquid partition in the system propylene carbonate-organic solvent and their use for estimating descriptors for organic compounds. Karunasekara T and Poole CF J. Chromatogr. A. 1218(6), 809-16, (2011)


A chiral solvent effect in asymmetric organocatalysis. North M and Villuendas P Org. Lett. 12(10), 2378-81, (2010)


The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data. Lowe ER, Poet TS, Rick DL, et al. Toxicol. Sci. 108(2), 258-72, (2009)


Robust cycling of Li-O2 batteries through the synergistic effect of blended electrolytes. Kim BG, Lee JN, Lee DJ, et al. ChemSusChem 6(3), 443-8, (2013)


Density functional theory study of the role of anions on the oxidative decomposition reaction of propylene carbonate. Xing L, Borodin O, Smith GD, et al. J. Phys. Chem. A 115(47), 13896-905, (2011)


Theoretical insight into oxidative decomposition of propylene carbonate in the lithium ion battery. Xing L, Wang C, Li W, et al. J. Phys. Chem. B 113(15), 5181-7, (2009)


Carbonates: ecofriendly solvents for palladium-catalyzed direct 2-arylation of oxazole derivatives. Roger J, Verrier C, Le Goff R, et al. ChemSusChem 2(10), 951-6, (2009)


Dielectric spectroscopy and ultrasonic study of propylene carbonate under ultra-high pressures. Kondrin MV, Gromnitskaya EL, Pronin AA, et al. J. Chem. Phys. 137(8), 084502, (2012)


Heat capacity in the glass transition range modeled on the basis of heterogeneous dynamics. Richert R J. Chem. Phys. 134(14), 144501, (2011)


The reaction of primary aromatic amines with alkylene carbonates for the selective synthesis of bis-N-(2-hydroxy)alkylanilines: the catalytic effect of phosphonium-based ionic liquids. Selva M, Fabris M, Lucchini V, et al. Org. Biomol. Chem. 8(22), 5187-98, (2010)


Rh-catalyzed asymmetric hydrogenation of unsaturated lactate precursors in propylene carbonate. Schäffner B, Andrushko V, Holz J, et al. ChemSusChem 1(11), 934-40, (2008)


Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates. Mo G, Hu X, Liu S, et al. Eur. J. Pharm. Sci. 46(5), 329-35, (2012)


An optical microscopy study on the phase structure of poly(L-lactide acid)/poly(propylene carbonate) blends. Gao M, Ren Z, Yan S, et al. J. Phys. Chem. B 116(32), 9832-7, (2012)


Correlation between ion diffusional motion and ionic conductivity for different electrolytes based on ionic liquid. Kaur DP, Yamada K, Park JS, et al. J. Phys. Chem. B 113(16), 5381-90, (2009)


Organic carbonates as stabilizing solvents for transition-metal nanoparticles. Vollmer C, Thomann R, and Janiak C Dalton Trans. 41(32), 9722-7, (2012)


Selective double quantum resolved correlation experiment for the complete separation of entire proton NMR spectra of enantiomers. Hebbar S, Prabhu UR, and Suryaprakash N J. Magn. Reson. 215, 23-6, (2012)


Visualization of enantiomers using natural abundant (13)C-filtered single and double quantum selective refocusing experiments: Application to small chiral molecules. Nath N, Baishya B, and Suryaprakash N J. Magn. Reson. 200(1), 101-8, (2009)


Greening pharmaceutical applications of liquid chromatography through using propylene carbonate-ethanol mixtures instead of acetonitrile as organic modifier in the mobile phases. Tache F, Udrescu S, Albu F, et al. J. Pharm. Biomed. Anal. 75, 230-8, (2013)


Demixing of severely overlapped ¹H NMR resonances and interpretation of anomalous intensity pattern of dipolar coupled A₃ spins in a weakly aligning medium. Nath N and Suryaprakash N J. Magn. Reson. 207(2), 190-6, (2010)


Biocompatibility evaluation of electrospun aligned poly (propylene carbonate) nanofibrous scaffolds with peripheral nerve tissues and cells in vitro. Wang Y, Zhao Z, Zhao B, et al. Chin. Med. J. 124(15), 2361-6, (2011)


Polymer synthesis: making the gradient. Lee BY and Cyriac A Nature Chemistry 3(7), 505-7, (2011)


Beil. 19,V,4,21

Aldrich MSDS 1, 1551:A / Corp MSDS 1 (2), 2965:D / FT-IR 1 (1), 613:A / FT-IR 2 (1), 979:B / FT-NMR 1 (1), 932:C / IR-Spectra (2), 325:F / IR-Spectra (3), 366:A / NMR-Reference 2 (1), 518:A / RegBook 1 (1), 697:D / Sax 6, 642 / Structure Index 1, 105:A:9 / Vapor Phase 3, 635:C

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