Synonym: Daunomycin hydrochloride
|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,|
|suitability||meets USP testing specifications|
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Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.1,2 Strong inhibitor of DNA and RNA synthesis.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. Properties
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P281-P301 + P310-P342 + P311|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-40-42/43|
|Safety Statements (Europe)||22-36/37-45|
|RIDADR||UN 2811 6.1 / PGIII|
Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Transfection
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
1. Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. Gong, Y., et al. J. Biol. Chem. 278, 50234-50239, (2003)
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Petersdorf SH, Kopecky KJ, Slovak M, et al. Blood 121(24), 4854-60, (2013)
The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. Xiang L, Li M, Liu Y, et al. Ann. Hematol. 92(8), 1063-9, (2013)
Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States. Kavcic M, Fisher BT, Li Y, et al. Cancer 119(10), 1916-23, (2013)
Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia. Bertoli S, Bérard E, Huguet F, et al. Blood 121(14), 2618-26, (2013)
High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission. Hassanein M, Atenafu EG, Schuh AC, et al. Leuk. Res. 37(5), 556-60, (2013)
Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study. Krug U, Koschmieder A, Schwammbach D, et al. PLoS ONE 7(12), e52695, (2012)
S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity. Hartmanová T, Tambor V, Lenčo J, et al. Chem. Biol. Interact. 202(1-3), 136-45, (2013)
Randomized trial comparing liposomal daunorubicin with idarubicin as induction for pediatric acute myeloid leukemia: results from Study AML-BFM 2004. Creutzig U, Zimmermann M, Bourquin JP, et al. Blood 122(1), 37-43, (2013)
Artesunate has its enhancement on antibacterial activity of β-lactams via increasing the antibiotic accumulation within methicillin-resistant Staphylococcus aureus (MRSA). Jiang W, Li B, Zheng X, et al. J. Antibiot. 66(6), 339-45, (2013)
Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation. Doughty B, Rao Y, Kazer SW, et al. Proc. Natl. Acad. Sci. U. S. A. 110(15), 5756-8, (2013)
2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein. Jabeen I, Wetwitayaklung P, Chiba P, et al. J. Comput. Aided Mol. Des. 27(2), 161-71, (2013)
Oxidized porous silicon particles covalently grafted with daunorubicin as a sustained intraocular drug delivery system. Chhablani J, Nieto A, Hou H, et al. Invest. Ophthalmol. Vis. Sci. 54(2), 1268-79, (2013)
Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group. Kaspers GJ, Zimmermann M, Reinhardt D, et al. J. Clin. Oncol. 31(5), 599-607, (2013)
High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation. Marshall GM, Dalla Pozza L, Sutton R, et al. Leukemia 27(7), 1497-503, (2013)
R.J. White et al. Drugs Pharm. Sci. 22, 569, (1984)
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