Daunorubicin hydrochloride
meets USP testing specifications
DOWNLOAD MSDS (PDF)Synonym: Daunomycin hydrochloride
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CAS Number 23541-50-6
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Empirical Formula (Hill Notation) C27H29NO10 · HCl
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Molecular Weight 563.98
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Beilstein Registry Number 4229221
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EC Number 245-723-4
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MDL number MFCD04974507
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PubChem Substance ID 24894229
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, |
| suitability | meets USP testing specifications |
| storage temp. | 2-8°C |
Description
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Biochem/physiol Actions
Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.1,2 Strong inhibitor of DNA and RNA synthesis.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. Properties
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