Streptomycin sulfate salt powder

Properties

Related Categories	Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antimycobacterial, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Core Bioreagents, Gene Regulation and Expression, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, RNA-Protein Translation Inhibitors, Research Essentials, Spectrum of Activity More...
form	powder
potency	≥720 I.U. per mg
mol wt	calculated mol wt 1457.38 ((C₂₁H₃₉N₇O₁₂)₂ ⋅3H₂O₄S)
color	white to off-white
storage temp.	2-8°C

Description

Application

Used to inhibit bacterial protein synthesis at the level of initiation inhibition.

Biochem/physiol Actions

Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Price and Availability

Related Papers

Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. Patrizia Pellegatti et al PLoS ONE 3, e2599, (2008)

Documents

Certificate of Analysis

Certificate of Origin

S6501 - Product Information Sheet (53 KB)

Safety Information

Symbol	GHS07, GHS08
Signal word	Warning
Hazard statements	H302-H361
Precautionary statements	P281
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes (Europe)	Xn
Risk Statements (Europe)	63-22
Safety Statements (Europe)	36/37
WGK Germany	3
RTECS	WK4990000

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere wi...
BioFiles 2006, 1.4, 17.
Keywords: Antibiotics, Environmental, Peptide synthesis