|Related Categories||Angiotensins, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,|
|solubility||H2O: soluble1.0 mg/mL, clear, colorless|
Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor.1 Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release2 and a stimulator for aldosterone release.3
Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 10385.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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1. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension Wright, J.W., et al. Int. J. Hypertens., doi: 10.1155/2012/124758, (2011)
2. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release Zini, S., et al. Proc. Natl. Acad. Sci. U. S. A. 93, 11968-73, (1996)
3. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor Yatabe, J., et al. Endocrinology 152, 1582-8, (2011)
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