|Related Categories||Angiotensins, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,|
|solubility||H2O: soluble1.0 mg/mL, clear, colorless|
Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor.1 Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release2 and a stimulator for aldosterone release.3
Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 10385.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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Different receptors/binding sites have been identified for the biologically active angiotensin (Ang) peptides, i.e. Ang II (1-8), Ang III (2-8), Ang IV (3-8) and Ang (1-7), based on the availability ...
1. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension Wright, J.W., et al. Int. J. Hypertens., doi: 10.1155/2012/124758, (2011)
2. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release Zini, S., et al. Proc. Natl. Acad. Sci. U. S. A. 93, 11968-73, (1996)
3. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor Yatabe, J., et al. Endocrinology 152, 1582-8, (2011)
Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction. Huang BS, Ahmad M, White RA, et al. Cardiovasc. Res. 97(3), 424-31, (2013)
Effects of angiotensin III on protein, DNA, and collagen synthesis of neonatal cardiomyocytes and cardiac fibroblasts in vitro. Wang HX, Zhang QF, Zeng XJ, et al. J. Cardiovasc. Pharmacol. Ther. 15(4), 393-402, (2010)
Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer. del Pilar Carrera M, Ramírez-Expósito MJ, Mayas MD, et al. Tumour Biol. 31(6), 583-8, (2010)
Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. Moltzer E, Verkuil AV, van Veghel R, et al. Hypertension 55(2), 516-22, (2010)
The influence of peptides from the angiotensin family on tyrosine kinase activity and cell viability in a human hormone-dependent prostate cancer line. Domińska K, Piastowska AW, Rebas E, et al. Endokrynol. Pol. 60(5), 363-9, (2009)
Influence of dietary sodium on the blood pressure and renal sympathetic nerve activity responses to intracerebroventricular angiotensin II and angiotensin III in anaesthetized rats. Houghton BL, Huang C, and Johns EJ Exp. Physiol. 95(2), 282-95, (2010)
Mammalian AT2 receptors expressed in Xenopus laevis oocytes couple to endogenous chloride channels and stimulate germinal vesicle break down. Reyes R, Pulakat L, Miledi R, et al. Cell Physiol. Biochem. 24(1-2), 45-52, (2009)
Brain AT1 angiotensin receptor subtype binding: importance of peptidase inhibition for identification of angiotensin II as its endogenous ligand. Karamyan VT, Gadepalli R, Rimoldi JM, et al. J. Pharmacol. Exp. Ther. 331(1), 170-7, (2009)
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