|Related Categories||A - H, Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis,|
|optical activity||[α]20/D +24±2°, c = 1.2% in 6 M HCl|
|mp||≥220 °C (dec.)(lit.)|
L-2,4-Diaminobutyric acid (DAB) is a substrate of diaminobutyrate-pyruvate transaminase (EC 220.127.116.11), an enzyme involved in an alternative polyamine biosynthesis pathway in bacteria.
L-2,4-Diaminobutyric acid (DAB, DABA), a non-metabolized amino acid, is useful as a selective GABA uptake inhibitor which may have antitumour activity against hepatoma cells.
Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli. Louis P, Galinski EA. Microbiology 143, 1141-1149, (1997)
Functional characterization of an aminotransferase required for pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa PAO1. Vandenende CS, Vlasschaert M, Seah SY. J. Bacteriol. 186, 5596-5602, (2004)
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. Lee J, Sperandio V, Frantz DE, Longgood J, et al. J. Biol. Chem. 284, 9899-9907, (2009)
Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions. Hoernke M, Schwieger C, Kerth A, et al. Biochim. Biophys. Acta 1818(7), 1663-72, (2012)
Elucidation of matrix effects and performance of solid-phase extraction for LC-MS/MS analysis of β-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) neurotoxins in cyanobacteria. Li A, Fan H, Ma F, et al. Analyst 137(5), 1210-9, (2012)
Distinguishing the cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB). Banack SA, Downing TG, Spácil Z, et al. Toxicon 56(6), 868-79, (2010)
Presence of the neurotoxic amino acids beta-N-methylamino-L-alanine (BMAA) and 2,4-diamino-butyric acid (DAB) in shallow springs from the Gobi Desert. Craighead D, Metcalf JS, Banack SA, et al. Amyotroph. Lateral Scler. 10 Suppl 2, 96-100, (2009)
Leifsonia pindariensis sp. nov., isolated from the Pindari glacier of the Indian Himalayas, and emended description of the genus Leifsonia. Reddy GS, Prabagaran SR, and Shivaji S Int. J. Syst. Evol. Microbiol. 58(Pt 9), 2229-34, (2008)
Leucobacter chromiireducens subsp. solipictus subsp. nov., a pigmented bacterium isolated from the nematode Caenorhabditis elegans, and emended description of L. chromiireducens. Muir RE and Tan MW Int. J. Syst. Evol. Microbiol. 57(Pt 12), 2770-6, (2007)
Heterologous expression, purification, and characterization of an l-ornithine N(5)-hydroxylase involved in pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa. Ge L and Seah SY J. Bacteriol. 188(20), 7205-10, (2006)
LC-MS/MS determination of the isomeric neurotoxins BMAA (beta-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Krüger T, Mönch B, Oppenhäuser S, et al. Toxicon 55(2-3), 547-57, (2010)
Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4,5-aminomutase. Wolthers KR, Rigby SE, and Scrutton NS J. Biol. Chem. 283(50), 34615-25, (2008)
Antitumor effects of the MIG and IP-10 genes transferred with poly [D,L-2,4-diaminobutyric acid] on murine neuroblastoma. Tominaga M, Iwashita Y, Ohta M, et al. Cancer Gene Ther. 14(8), 696-705, (2007)
Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis. Müller C, Nolden S, Gebhardt P, et al. Antimicrob. Agents Chemother. 51(3), 1028-37, (2007)
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