|Related Categories||Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Chemical Class,|
mouse ... Aldh1a2(19378), Maoa(17161)|
rat ... Aldh1a2(116676)
Daidzin is an isoflavone reported to have anti-oxidant, anti-carcinogenic, and anti-artherosclerotic activities. Daidzin is the major active component of the traditional Chinese medicine (TCM) derived from radix puerariae (Kudzu) that is commonly used to treat alcohol abuse. Daidzin is a potent and selective inhibitor of mitochondrial aldehyde dehydrogenase 2 (ALDH-2).
Daidzin was the most potent isoflavone glycoside tested in modulating differentiation of bone marrow stromal cells toward osteoblasts and away from adipocytes.1
Bottomless glass bottle. Contents are inside inserted fused cone.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 30408.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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Histamine is a biogenic amine that stimulates multiple histamine receptor types. In mammals, histamine is found within granules of basophils and mast cells (>90% of body stores) and within tuberomamm...
Keywords: Atomic layer deposition, Cardiovascular, Ligands, Metabolism, Methylations, Microwave synthesis, Oxidations
1. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts Li, X.H., et al. Acta Pharmacol. Sin. 26, 1081-1086, (2005)
Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. Lang BS, Gorren AC, Oberdorfer G, et al. J. Biol. Chem. 287(45), 38124-34, (2012)
Antioxidant characterization of soy derived products in vitro and the effect of a soy diet on peripheral markers of oxidative stress in a heart disease model. Hagen MK, Ludke A, Araujo AS, et al. Can. J. Physiol. Pharmacol. 90(8), 1095-103, (2012)
Simultaneous analysis and retention behavior of major isoflavonoids in Radix Puerariae lobatae and Radix Puerariae thomsonii by high performance liquid chromatography with cyclodextrins as a mobile phase modifier. Zeng A, Xing J, Wang C, et al. Anal. Chim. Acta 712, 145-51, (2012)
Comparison of the effects of antimicrobial agents from three different classes on metabolism of isoflavonoids by colonic microflora using Etest strips. Sutherland JB, Bridges BM, Heinze TM, et al. Curr. Microbiol. 64(1), 60-5, (2012)
Preparation of highly pure daidzin on oligo-β-cyclodextrin-Sepharose HP and investigation of chromatographic behavior of isoflavones by molecular docking. Yang L, Li C, Yuan T, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(20), 1773-80, (2011)
A model for the shuttle motions of puerarin and daidzin inside the cavity of β-cyclodextrin in aqueous acetic acid: insights from molecular dynamics simulations. Zhang H, Feng W, Li C, et al. J. Mol. Model. 18(1), 221-7, (2012)
Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. Zhao C, Chan HY, Yuan D, et al. Phytochem. Anal. 22(6), 503-8, (2011)
Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway. Zhang P, Xu D, Wang S, et al. Biomed. Pharmacother. 65(8), 590-3, (2011)
The effects of different lignans and isoflavones, tested as aglycones and glycosides, on hormone receptor-positive and -negative breast carcinoma cells in vitro. Theil C, Briese V, Gerber B, et al. Arch. Gynecol. Obstet. 284(2), 459-65, (2011)
Enzyme-linked immunosorbent assay for total isoflavonoids in Pueraria candollei using anti-puerarin and anti-daidzin polyclonal antibodies. Pongkitwitoon B, Sakamoto S, Tanaka H, et al. Planta Med. 76(8), 831-6, (2010)
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