|Related Categories||1.5.x.x Acting on CH-NH, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates,|
|form||ammonium sulfate suspension|
|activity||≥6 U/mg protein|
|density||1.2 g/mL at 20 °C|
In folate metabolism for the synthesis of purines, thymidine and glycine3
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1 U corresponds to the amount of enzyme which converts 1 μmol 7,8-dihydrofolate and NADPH to 5,6,7,8-tetrahydrofolate and NADP per minute at pH 6.5 and 25 °C
Suspension in 3.6 M ammonium sulfate solution, pH 7.0
Dihydrofolate reductase (DHFR) is involved in the synthesis of purines, thymidine and glycine in folate metabolism. DHFR, from bovine liver, is used for methotrexate analysis 1. DHFR is useful to study various cancers such as sarcomas, leukemias and head and neck cancers 2.
Dihydrofolate reductase (DHFR) reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor. The binding of antitumor agents, such as methotrexate, to DHFR prevents the formation of reduced folates, which are essential for DNA synthesis 2.
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