|Related Categories||Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Glycine Derivatives,|
Reagent for the irreversible inactivation of γ-cystathionase1,2; affinity labeling reagent for γ-cystathionase and other enzymes3; peptides containing this amino acid can be tritiated to high specific radioactivity4
L-C-Propargylglycine, a specific inhibitor of H(2)S synthase of cystathionine-γ-lyase (CSE), may be used to study the role of H2S in regulation of biological processes.
L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), is useful in studies of hydrogen sulphide synthesis and bioactivity.
Aldrich Chemistry lists over 600 alkyne building blocks, including a wide array of propargyl alcohols, acetylenic boron reagents, and halogenated substrates for cross-coupling. Additionally, many of ...
Keywords: Building blocks, Coupling reactions, Cross couplings
4. A.N. Eberle, A. Zeller Helv. Chim. Acta 68, 1880, (1985)
Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat. Chávez-Piña AE, Tapia-Alvarez GR, Navarrete A. Eur. J. Pharmacol. 630, 131-136, (2010)
Hydrogen sulfide modulates sinusoidal constriction and contributes to hepatic microcirculatory dysfunction during endotoxemia. Norris EJ, Feilen N, Nguyen NH, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(12), G1070-8, (2013)
Hydrogen sulfide in the mouse ductus arteriosus: a naturally occurring relaxant with potential EDHF function. Baragatti B, Ciofini E, Sodini D, et al. Am. J. Physiol. Heart Circ. Physiol. 304(7), H927-34, (2013)
The role of endogenous hydrogen sulfide in pathogenesis of chronotropic dysfunction in rats with cirrhosis. Babaei-Karamshahlou M, Hooshmand B, Hajizadeh S, et al. Eur. J. Pharmacol. 696(1-3), 130-5, (2012)
Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. Dam VP, Scott JL, Ross A, et al. Eur. J. Pharmacol. 685(1-3), 165-73, (2012)
Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung. Madden JA, Ahlf SB, Dantuma MW, et al. J. Appl. Physiol. 112(3), 411-8, (2012)
[Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in spontaneously hypertensive rats]. Strutyns'ka NA, Dorofeieva NO, Vavilova HL, et al. Fiziol. Zh. 59(1), 3-10, (2013)
Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin. Francescato HD, Chierice JR, Marin EC, et al. Braz. J. Med. Biol. Res. 45(3), 244-9, (2012)
MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. Yang G, Pei Y, Cao Q, Wang R. J. Cell Physiol. 227(9), 3192-200, (2011)
Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is h(2) S a novel cytoprotective mediator in the inflamed joint? Fox B, Schantz JT, Haigh R, et al. J. Cell. Mol. Med. 16(4), 896-910, (2012)
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