L-C-Propargylglycine ≥99.0% (TLC)

Properties

Related Categories	Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Glycine Derivatives, I - Z, Modified Amino Acids, Peptide Chemistry, Unnatural Amino Acid Derivatives More...
assay	≥99.0% (TLC)
storage temp.	2-8°C

Description

Application

Reagent for the irreversible inactivation of γ-cystathionase^1,²; affinity labeling reagent for γ-cystathionase and other enzymes³; peptides containing this amino acid can be tritiated to high specific radioactivity⁴

Biochem/physiol Actions

L-C-Propargylglycine, a specific inhibitor of H(2)S synthase of cystathionine-γ-lyase (CSE), may be used to study the role of H2S in regulation of biological processes.

L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), is useful in studies of hydrogen sulphide synthesis and bioactivity.

Price and Availability

Related Papers

1. Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine. W. Washtier, R.H. Abeles Biochemistry 16, 2485, (1977)

Documents

Certificate of Analysis

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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1. Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine. W. Washtier, R.H. Abeles Biochemistry 16, 2485, (1977)

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2. Effect of L-propargylglycine on metabolism of sulfur-containing amino acids in pregnant rats and their fetuses. K. Sasaki et al. Biochem. Int. 10, 165, (1985)

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3. Metabolic consequences of affinity labeling of cystathionase and alanine aminotransferase by L-propargylglycine in vivo. S. Shinozuka et al. Eur. J. Biochem. 124, 377, (1982)

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4. A.N. Eberle, A. Zeller Helv. Chim. Acta 68, 1880, (1985)

Hydrogen sulphide regulates calcium homeostasis in microglial cells. Lee SW, Hu YS, Hu LF, Lu Q, et al. Glia 54, 116-124, (2006)

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Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat. Chávez-Piña AE, Tapia-Alvarez GR, Navarrete A. Eur. J. Pharmacol. 630, 131-136, (2010)

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Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells. Pupo E, Pla AF, Avanzato D, et al. Free Radic. Biol. Med. 51, 1765-1773, (2011)

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Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. Tan G, Pan S, Li J, Dong X, et al. PLoS ONE 6, e25943, (2011)

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Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility. Gil V, Gallego D, Jiménez M. Br. J. Pharmacol. 164(2b), 485-98, (2011)

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NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca⁽²⁺⁾ channel. Tian XY, Wong WT, Sayed N, et al. Pharmacol. Res. 65(2), 239-46, (2011)

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MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. Yang G, Pei Y, Cao Q, Wang R. J. Cell Physiol. 227(9), 3192-200, (2011)

Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is h(2) S a novel cytoprotective mediator in the inflamed joint? Fox B, Schantz JT, Haigh R, et al. J. Cell. Mol. Med. 16(4), 896-910, (2012)

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