Colupulone
mixture of homologues, ≥85% (HPLC)
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PubChem Substance ID 24890337
Properties
| Related Categories | Alcohols, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Class, |
| assay | ≥85% (HPLC) |
| storage temp. | −20°C |
Description
Analysis Note
predominantly colupulone and lupulone
Biochem/physiol Actions
Colupulone is a bitter acid extracted from HOPS which activates transcription of xenobiotic metabolism via the human nuclear pregnane X receptor.
Mixture of predominantly colupulone and lupulone is an activator of the extrinsic apoptotic pathway via TRAIL DR4/DR5 death receptors and antimicrobial agent.
Protocols & Applications
Hops (Humulus lupulus) Plant Profile: bioactives, mechanism of action, references
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