|Related Categories||AN-AZ, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,|
|optical activity||[α]27/D +12°, c = 1 in methanol(lit.)|
|solubility||ethanol: soluble1 mg/mL (stable at least a week at 4°C.)|
|DMSO: soluble10 mg/mL (stable at least six weeks at −20°C.)|
|methanol: soluble10 mg/mL|
|Gene Information||human ... POLA1(5422), POLD1(5424), POLG(5428)|
Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.
Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.
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Certificate of Origin
Augmentation by aphidicolin of 1-β-D-arabinofuranosylcytosine-induced c-jun and NF-kappa B activation in a human myeloid leukemia cell line: correlation with apoptosis. Kuwakado, K., et al. Leuk. Res. 19, 645, (1995)
How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus). McAllister, B.F., and Greenbaum, I.F. Hum. Genet. 100, 182-188, (1997)
The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Llopis A, Salvador N, Ercilla A, et al. Cell Cycle 11(19), 3627-37, (2012)
Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells. Amsailale R, Van Den Neste E, Arts A, et al. Biochem. Pharmacol. 84(1), 43-51, (2012)
Positive effects of treatment of donor cells with aphidicolin on the preimplantation development of somatic cell nuclear transfer embryos in Chinese Bama mini-pig (Sus Scrofa). Zhang TY, Dai JJ, Wu CF, et al. Anim. Sci. J. 83(2), 103-10, (2012)
Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae. Fujii R, Minami A, Tsukagoshi T, et al. Biosci. Biotechnol. Biochem. 75(9), 1813-7, (2011)
Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. Deng W, Tsao SW, Guan XY, et al. PLoS ONE 7(10), e48576, (2012)
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