A0972 Sigma

Apolipoprotein A-II from human plasma

≥95% (SDS-PAGE), buffered aqueous solution

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Synonym: Apo A-II

Description

Application

Apo A-II constitutes ~20% of the protein moiety of high density lipoprotein (HDL).

Biochem/physiol Actions

Unlike Apo A-I, Apo A-II possesses no activating properties for lectin-cholesterol acyltransferase (LCAT). Furthermore, it was found that Apo A-II inhibits the activation of LCAT by Apo A-I.

General description

Forms dimers in aqueous solutions with an association constant of 5 × 104 M-1. The association is accompanied by an enhancement of ~35% in α-helical content.

Physical form

Solution in 10 mM ammonium bicarbonate.

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