Synonym: ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
CAS Number 60-32-2
Linear Formula H2N(CH2)5CO2H
Molecular Weight 131.17
Beilstein Registry Number 906872
EC Number 200-469-3
MDL number MFCD00008238
PubChem Substance ID 24890662
Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF) | FTIR (PDF)
| Related Categories | A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, |
| assay | ≥99% (titration) |
| form | powder |
| color | white |
| mp | 207-209 °C (dec.)(lit.) |
| solubility | H2O: soluble50 mg/mL |
| Gene Information |
human ... PLG(5340) rat ... Ppm1a(24666) |
1 kg in poly bottle
25, 100, 500 g in poly bottle
5 kg in poly drum
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
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