N-Acetyl-L -tryptophan 3,5-bis(trifluoromethyl)benzyl ester
≥99% (TLC), powder
DOWNLOAD MSDS (PDF)Synonym: L-732,138
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CAS Number 148451-96-1
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Empirical Formula (Hill Notation) C22H18F6N2O3
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Molecular Weight 472.38
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MDL number MFCD00237267
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PubChem Substance ID 24277690
Properties
| Related Categories | A-AM, Antagonist, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, |
| assay | ≥99% (TLC) |
| form | powder |
| mp | 147-148 °C(lit.) |
| storage temp. | −20°C |
| Gene Information | human ... TACR1(6869) |
Description
Biochem/physiol Actions
Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.
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