Monoclonal Anti-c-Abl antibody produced in mouse
clone ABL-148, ascites fluid
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MDL number MFCD00239646
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Properties
| Related Categories | A, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle, |
| species reactivity | monkey, mouse, human, rat, bovine |
| application(s) | flow cytometry: suitable |
| immunocytochemistry: suitable | |
| immunoprecipitation: suitable | |
| microarray: suitable | |
| western blot: 1:2,000 using human melanoma cell extract | |
| clone | ABL-148, monoclonal |
| antibody form | ascites fluid |
| isotype | IgG2a |
| mol wt | antigen mol wt 145 kDa |
| shipped in | dry ice |
| storage temp. | −20°C |
| Gene Information |
human ... ABL1(25) mouse ... Abl1(11350) rat ... Abl1(311860) |
Description
Immunogen
recombinant c-Abl, SH2 domain.
General description
c-Abl is a proto-oncogene product that belongs to Tyr protein kinase family. It has a crucial role in different cellular processes like- differentiation, adhesion and regulates DNA damage-induced apoptosis2,3. Monoclonal anti-c-Abl antibody can be used for studying the mechanism of signaling pathways involving c-Abl. It may also be used for immunoprecipitation and immunocytochemistry. Mouse anti-c-Abl antibody reacts specifically with an epitope present in the SH2 domain of the c-Abl. The product has also shown reactivity for c-Abl of monkey, rat, bovine, mouse and human.
Antigen Background
c-Abl is a non-receptor tyrosine kinase with both cytoplasmic and nuclear functions. The Abl oncogen has been implicated in several human leukemias including nearly all chronic myelocytic leukemias.
Application
Hippocampal extracts from rats were analyzed by western blot using anti-phospho TYR412 c-Abl as the primary antibody at a dilution of 1:1000. 1
Monoclonal anti-c-Abl antibody can be used in western blotting (diluted 1:2000) using melanoma cell extract from human. It can also be used in microarray and flow cytometry.
Price and Availability
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