|Related Categories||A, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle,|
|species reactivity||monkey, mouse, human, rat, bovine|
|application(s)||flow cytometry: suitable|
|western blot: 1:2,000 using human melanoma cell extract|
|antibody form||ascites fluid|
|mol wt||antigen mol wt 145 kDa|
|shipped in||dry ice|
human ... ABL1(25)|
mouse ... Abl1(11350)
rat ... Abl1(311860)
recombinant c-Abl, SH2 domain.
c-Abl is a proto-oncogene product that belongs to Tyr protein kinase family. It has a crucial role in different cellular processes like- differentiation, adhesion and regulates DNA damage-induced apoptosis2,3. Monoclonal anti-c-Abl antibody can be used for studying the mechanism of signaling pathways involving c-Abl. It may also be used for immunoprecipitation and immunocytochemistry. Mouse anti-c-Abl antibody reacts specifically with an epitope present in the SH2 domain of the c-Abl. The product has also shown reactivity for c-Abl of monkey, rat, bovine, mouse and human.
c-Abl is a non-receptor tyrosine kinase with both cytoplasmic and nuclear functions. The Abl oncogen has been implicated in several human leukemias including nearly all chronic myelocytic leukemias.
Hippocampal extracts from rats were analyzed by western blot using anti-phospho TYR412 c-Abl as the primary antibody at a dilution of 1:1000. 1
Monoclonal anti-c-Abl antibody can be used in western blotting (diluted 1:2000) using melanoma cell extract from human. It can also be used in microarray and flow cytometry.
A valuable measure of the knock-down potency of any RNAi experiment is the reduction in protein level. Displayed below are the knock-down rates of selected esiRNAs using quantitative western blot an...
Keywords: Cell proliferation, Gene expression, PAGE, Reductions, Transfection, Western blot
As a leading supplier of antibodies, Sigma® Life Science is committed to providing researchers the antibody they need with the quality they deserve. Our Antibody Explorer Search Tool provides easy ac...
Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?