|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
|biological source||from Streptomyces parvulus|
|solubility||DMSO: soluble1 mg/mL|
|methanol: soluble1 mg/mL|
|shipped in||wet ice|
Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.
Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors. Maria-Teresa Gutierrez-Lugo et al Bioorg. Med. Chem. Lett. 21, 2480-3, (2011)
Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura, T., et al. J. Antibiot. 56, 709-715, (2003)
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