|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
|biological source||from Streptomyces parvulus|
|solubility||DMSO: soluble1 mg/mL|
|methanol: soluble1 mg/mL|
|shipped in||wet ice|
Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.
Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean [Glycine max (L.) Merr]. Liu C, Wang X, Yan Y, et al. Int. J. Syst. Evol. Microbiol. 63(Pt 3), 1030-6, (2013)
Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Habibi D, Ogloff N, Jalili RB, et al. Invest. New Drugs 30(4), 1361-70, (2012)
Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation. Vergnolle O, Hahn F, Baerga-Ortiz A, et al. ChemBioChem. 12(7), 1011-4, (2011)
Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies. Mariner KR, Ooi N, Roebuck D, et al. Antimicrob. Agents Chemother. 55(4), 1784-6, (2011)
Iterative deoxypropionate synthesis based on a copper-mediated directed allylic substitution: formal total synthesis of borrelidin (C3-C11 fragment). Herber C and Breit B Chemistry 12(25), 6684-91, (2006)
All-catalytic, efficient, and asymmetric synthesis of alpha,omega-diheterofunctional reduced polypropionates via "one-pot" Zr-catalyzed asymmetric carboalumination-Pd-catalyzed cross-coupling tandem process. Novak T, Tan Z, Liang B, et al. J. Am. Chem. Soc. 127(9), 2838-9, (2005)
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Olano C, Wilkinson B, Sánchez C, et al. Chem. Biol. 11(1), 87-97, (2004)
Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. Hanessian S, Yang Y, Giroux S, et al. J. Am. Chem. Soc. 125(45), 13784-92, (2003)
Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors. Maria-Teresa Gutierrez-Lugo et al Bioorg. Med. Chem. Lett. 21, 2480-3, (2011)
Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura, T., et al. J. Antibiot. 56, 709-715, (2003)
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