B5386 Sigma

8-Bromoadenosine 3′,5′-cyclic monophosphate

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Synonym: 8-Br-cAMP

Description

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Caution

Sensitive to light and moisture.

Other Notes

Membrane-permeable cAMP analog.

Biochem/physiol Actions

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

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