C3633 Sigma


≥90% (HPLC)

Synonym: DL,DL-allo-Cystathionine, S-(2-Amino-2-carboxyethyl)homocysteine



Related Categories A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids
assay   ≥90% (HPLC)
storage temp.   2-8°C
Gene Information   human ... BHMT(635)


Other Notes

A mixture of 4 stereoisomers; L-, D-, L-allo- and D-allo-cystathionine.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C3633.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

Preparation Note

Prepared by method of Stekol.1

Biochem/physiol Actions

Cystathionine is an intermediate in the biosynthesis of the amino acid cysteine. Cystathionine is used as a substrate to differentiate and analyze cystathionine gamma-lyase(s).

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Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


Set your institution to view full text papers.

1. A new synthesis of S-(beta-amino-beta-carboxyethyl) homocysteine (cystathionine) and S-bis(gamma-amino-gamma -carboxypropyl) sulfide (homolanthionine). Stekol, J.A. J. Biol. Chem. 173, 153, (1948)


Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry. González-Domínguez R, García A, García-Barrera T, et al. Electrophoresis 35(23), 3321-30, (2014)


Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling. Kundu S, Pushpakumar S, Khundmiri SJ, et al. Biochim. Biophys. Acta 1843(12), 2816-26, (2014)


Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes. Rios-Avila L, Coats B, Chi YY, et al. J. Nutr. 145(1), 87-95, (2015)


Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. Hu N, Dong M, Ren J, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306(10), R761-71, (2014)


Ablation of MMP9 gene ameliorates paracellular permeability and fibrinogen-amyloid beta complex formation during hyperhomocysteinemia. Muradashvili N, Tyagi R, Metreveli N, et al. J. Cereb. Blood Flow Metab. 34(9), 1472-82, (2014)


Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate. Melenovská P, Kopecká J, Krijt J, et al. J. Inherit. Metab. Dis. 38(2), 287-94, (2015)


MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator. Kundu S, Pushpakumar S, Sen U, et al. Nitric Oxide 46, 172-85, (2015)


Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats. Perez CM, Hazari MS, Ledbetter AD, et al. Inhal. Toxicol. 27(1), 54-63, (2015)


S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. Jiri Jiracek et al J. Med. Chem. 49, 3982-9, (2006)


Beil. 4,IV,3197

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