Complement factor I from human plasma >90% (SDS-PAGE)

Properties

Related Categories	3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement, Complement Factor Proteins, Complement Proteins, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives, Proteolytic Enzymes, Proteolytic Enzymes and Substrates More...
assay	>90% (SDS-PAGE)
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... CFI(3426)

Description

Biochem/physiol Actions

Protease which cleaves and inactivates C3b and C4b

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Physical form

Supplied as a 1mg/ml solution in PBS, pH 7.2

Application

Complement factor I from human plasma has been used in a case study of glucose-starved Staphylococcus aureus. Complement factor I from human plasma has also been used to study the human complement cascade of proteolysis as a target of laser irradiation.

Price and Availability

Related Papers

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. Pangburn, M.K., et al. J. Exp. Med. 146, 257, (1977)

Documents

Certificate of Analysis

Certificate of Origin

Enzyme Explorer

Safety Information

Safety Information for this product is unavailable at this time.

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Gas chromatography

Papers

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Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. Pangburn, M.K., et al. J. Exp. Med. 146, 257, (1977)

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Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b. Park, S.Y., et al. J. Histochem. Cytochem. 181, 6328-36, (2008)

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The study of the human complement cascade of proteolysis as a target of laser irradiation Galebskaia, L., et al. Biomed. Khim. 55, 68-72, (2012)

Factor H-related protein 4 activates complement by serving as a platform for the assembly of an alternative pathway C3 convertase via its interaction with C3b Hebecker, M. and M. Jozsi J. Biol. Chem. 287(23), 19258-36, (2012)

Life and death of proteins: A case study of glucose-starved Staphylococcus aureus Michalik, S., et al. Mol. Cell. Proteomics 11(9), 558-70, (2012)

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