|Related Categories||3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes,|
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|Gene Information||human ... CFI(3426)|
Protease which cleaves and inactivates C3b and C4b
Supplied as a 1mg/ml solution in PBS, pH 7.2
Complement factor I from human plasma has been used in a case study of glucose-starved Staphylococcus aureus. Complement factor I from human plasma has also been used to study the human complement cascade of proteolysis as a target of laser irradiation.
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Keywords: Gas chromatography
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Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. Pangburn, M.K., et al. J. Exp. Med. 146, 257, (1977)
The study of the human complement cascade of proteolysis as a target of laser irradiation Galebskaia, L., et al. Biomed. Khim. 55, 68-72, (2012)
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Brouwers N, Van Cauwenberghe C, Engelborghs S, et al. Mol. Psychiatry 17(2), 223-33, (2012)
No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration. Cipriani V, Matharu BK, Khan JC, et al. Eur. J. Hum. Genet. 20(1), 1-2; author reply 3, (2012)
Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. Smailhodzic D, Klaver CC, Klevering BJ, et al. Ophthalmology 119(2), 339-46, (2012)
Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon? Kavanagh D, Pappworth IY, Anderson H, et al. Clin. J. Am. Soc. Nephrol. 7(3), 417-26, (2012)
Complement factor I deficiency: a not so rare immune defect: characterization of new mutations and the first large gene deletion. Alba-Domínguez M, López-Lera A, Garrido S, et al. Orphanet J. Rare Dis. 7, 42, (2012)
Species selectivity in poxviral complement regulators is dictated by the charge reversal in the central complement control protein modules. Yadav VN, Pyaram K, Ahmad M, et al. J. Immunol. 189(3), 1431-9, (2012)
Genetic, behavioral, and sociodemographic risk factors for second eye progression in age-related macular degeneration. Lechanteur YT, van de Ven JP, Smailhodzic D, et al. Invest. Ophthalmol. Vis. Sci. 53(9), 5846-52, (2012)
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. Broderick L, Gandhi C, Mueller JL, et al. J. Clin. Immunol. 33(1), 162-71, (2013)
Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism. Silva AS, Teixeira AG, Bavia L, et al. Mol. Vis. 18, 2288-99, (2012)
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. Nagasawa S, Ichihara C, and Stroud RM J. Immunol. 125(2), 578-82, (1980)
Factor H-related protein 4 activates complement by serving as a platform for the assembly of an alternative pathway C3 convertase via its interaction with C3b Hebecker, M. and M. Jozsi J. Biol. Chem. 287(23), 19258-36, (2012)
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