Clofibrate

Papers

Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity. Buchmann, A., et al. Cell Death Differ. 6, 190, (1999)

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Tissue-specific effect of clofibrate on rat lipogenic enzyme gene expression. Karbowska, J. Eur. J. Pharmacol. 370, 329, (1999)

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Drug treatment of lipid disorders. Knopp, R.H., et al. N. Engl. J. Med. 341, 498, (1999)

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Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis). Masayuki Yoshikawa et al J. Nat. Prod. 68, 1360-5, (2005)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists. Maria Grazia Perrone et al Bioorg. Med. Chem. 16, 2473-88, (2008)

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Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis. Toshio Morikawa et al J. Nat. Prod. 71, 828-35, (2008)

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Probing the fibrate binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 52, 5344-55, (2009)

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Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives. Gamal A Idrees et al Eur. J. Med. Chem. 44, 2679-84, (2009)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

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Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents. Alaa A-M Abdel-Aziz et al Eur. J. Med. Chem. 46, 4324-9, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Merck 14,2377

Beil. 6,IV,851