|Related Categories||Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,|
|solubility||DMSO: soluble10 mg/mL|
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin,1 and in studies on cytokinesis.2 Probe for the two hexose-transport systems in rat L6 myoblasts.3
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
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≥95% (HPLC), powder
Ready Made Solution, 10 mg/mL in DMSO, 0.2 μm filtered
from Zygosporium mansonii, ≥98% (TLC and HPLC), powder
≥99% (TLC), powder
Certificate of Analysis
Certificate of Origin
|Hazard statements||H300 +H310 + H330-H361|
|Precautionary statements||P260-P264-P280-P284-P301 + P310-P302 + P350|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||63-26/27/28|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 1544 6.1/PG 2|
The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription
2. S. Eperon J. Protozool. 33, 43, (1986)
3. S.R.Chen Biochem. J. 251, 3, (1988)
Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin. Diaz-Ricart M., et al. Am. J. Pathol. 160, 329-337, (2002)
Effect Of Temperature During Irradiation On The Level Of Micronuclei In Human Peripheral Blood Lymphocytes Exposed To X-rays And Neutrons. Brzozowska, K., et al. Int. J. Radiat. Biol. 85, 891-9, (2009)
High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Lavrentyev, E.N., and Malik, K.U. Am. J. Physiol. Heart Circ. Physiol. 296, H106-18, (2009)
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