|Related Categories||Adenosines/P2 Nucleotide Receptor - Agonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecules, Biochemicals and Reagents,|
|color||white to off-white|
|solubility||H2O: soluble1.7 mg/mL|
|0.1 M HCl: soluble12 mg/mL|
|DMSO: soluble23 mg/mL|
human ... ADORA1(134), ADORA2A(135), ADORA3(140)|
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
Selective A1 adenosine receptor agonist.
Certificate of Analysis
There are four known subtypes of adenosine receptors, referred to as A1, A2A, A2B and A3. All are members of the superfamily of G protein-coupled receptors and each bears the characteristic motif of ...
Keywords: Atomic absorption spectroscopy, Cancer, Cardiovascular, Diabetes, Diseases, Gene expression, Inflammation, Neurotransmitters, Substitutions, Transduction
Genetically controlled upregulation of adenosine A(1) receptor expression enhances the survival of primary cortical neurons. Serchov T, Atas HC, Normann C, et al. Mol. Neurobiol. 46(2), 535-44, (2012)
Activation of NTS A(1) adenosine receptors inhibits regional sympathetic responses evoked by activation of cardiopulmonary chemoreflex. Ichinose TK, Minic Z, Li C, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(5), R539-50, (2012)
Quantitative determination of zolmitriptan in rat blood and cerebrospinal fluid by reversed phase HPLC-ESI-MS/MS analysis: application to in vivo preclinical pharmacokinetic study. Dalpiaz A, Marchetti N, Cavazzini A, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 901, 72-8, (2012)
Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions. Zhang D, Xiong W, Albensi BC, et al. J. Neurochem. 118(1), 4-11, (2011)
Role of large-conductance Ca²+-activated K+ channels in adenosine A₁ receptor-mediated pharmacological postconditioning in H9c2 cells. Fretwell L and Dickenson JM Can. J. Physiol. Pharmacol. 89(1), 24-30, (2011)
Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart. Urmaliya VB, Pouton CW, Ledent C, et al. J. Cardiovasc. Pharmacol. 56(4), 379-88, (2010)
A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate. Urmaliya VB, Pouton CW, Devine SM, et al. J. Cardiovasc. Pharmacol. 56(3), 282-92, (2010)
Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury. Wang R, Urso ML, Zambraski EJ, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299(1), R259-67, (2010)
Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes. Xiang F, Huang YS, Zhang DX, et al. Clin. Exp. Pharmacol. Physiol. 37(3), 343-9, (2010)
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