Collagen from rat tail
Bornstein and Traub Type I (Sigma Type VII), powder
DOWNLOAD MSDS (PDF)-
CAS Number 9007-34-5
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EC Number 232-697-4
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MDL number MFCD00130825
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Biochemicals and Reagents, Collagen, Proteins and Derivatives, Structural Proteins |
| form | powder |
| solubility | aqueous acid: soluble |
| storage temp. | 2-8°C |
| Gene Information | rat ... Col1a1(29393) |
Description
General description
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Preparation Note
Prepared by a modification of the extraction method of Bornstein, M.B., Lab. Invest., 7, 134 (1958).
Application
Collagen Type I has been used as a scaffold for the growth in vitro of stem cells in a wide variety of biomaterial engineering studies.1,2
Collagen type I may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type 1 is one distinctive feature of IPF. Additionally, collagen-type 1 has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collage-type 1 soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.
Price and Availability
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