|Related Categories||Albumin, Biochemicals and Reagents, Modified Albumins, Proteins and Derivatives|
|extent of labeling||~10 mol Digoxin per mol albumin|
|Gene Information||cow ... ALB(280717)|
Lyophilized from 0.06 M Tris
Digoxin-BSA bovine is a cardioactive glycoside which can increase intracellular calcium concentration through Na+/K+-ATPase pump inhibition. Digoxin has been used in treatments of heart related disease and also studies of cancer treatments. It has shown the ability to inhibit prostate cancer cell growth, but has also shown a reduction in the efficiency of chemotherapy (reduced drug absorption) by increasing the amount of P-glycoprotein (Pgp).
Customers Also Viewed
lyophilized powder, ≥96% (agarose gel electrophoresis)
lyophilized powder, BioReagent, suitable for cell culture, ≥96% (agarose gel electrophoresis)
Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1á in human colon cancer cells Riganti, C., et al. Toxicol. Appl. Pharmacol. 240, 385-392, (2009)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?