|Related Categories||A to C, Akt, Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents,|
|color||white to yellow|
|solubility||DMSO: >10 mg/mL|
Inhibitor of activated Akt. Does not affect MAPK, ERK1/2, or JNK. Anticancer, chemoprotective agent.
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Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation
A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer. Suh YA, Kim JH, Sung MA, et al. Cancer Lett. 332(1), 102-9, (2013)
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. Chang DJ, An H, Kim KS, et al. J. Med. Chem. 55(24), 10863-84, (2012)
[Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway]. Chu ZH, Liang XH, Zhou XL, et al. Zhong Xi Yi Jie He Xue Bao 9(5), 533-8, (2011)
Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway. Thamilselvan V, Menon M, and Thamilselvan S Int. J. Cancer 129(12), 2916-27, (2011)
Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model. Hu J, Ye H, Fu A, et al. Int. J. Cancer 127(10), 2455-66, (2010)
Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Murillo G, Peng X, Torres KE, et al. Cancer Prev. Res. (Phila.) 2(11), 942-50, (2009)
Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. Ito S, Oyake T, Murai K, et al. Leuk. Res. 34(3), 352-7, (2010)
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Woo JK, Choi DS, Tran HT, et al. Cancer Prev. Res. (Phila.) 2(4), 361-9, (2009)
Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Kang HW, Kim JM, Cha MY, et al. Dig. Dis. Sci. 57(11), 2873-82, (2012)
A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. Rodenberg JM and Brown PH Cancer Prev. Res. (Phila.) 2(11), 915-8, (2009)
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