|Related Categories||A to C, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cholesterol esterase,|
|color||colorless to yellow|
|solubility||DMSO: >5 mg/mL|
Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50 = 11.6 μM.
|Precautionary statements||P264-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25|
|Safety Statements (Europe)||45|
|RIDADR||UN 2811 6.1 / PGII|
To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
Diethylumbelliferyl phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR). Choi YS, Stocco DM, and Freeman DA Eur. J. Biochem. 234(2), 680-5, (1995)
Evidence that a neutral cholesteryl ester hydrolase is responsible for the extralysosomal hydrolysis of high-density lipoprotein cholesteryl ester in rat hepatoma cells (Fu5AH). Delamatre JG, Carter RM, and Hornick CA J. Cell Physiol. 157(1), 164-8, (1993)
A rapid oxygen exchange on prostaglandins in plasma represents plasma esterase activity that is inhibited by diethylumbelliferyl phosphate with high affinity. Brose SA and Golovko MY Rapid Commun. Mass Spectrom. 26(20), 2472-6, (2012)
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