|Related Categories||A to C, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cholesterol esterase,|
|color||colorless to yellow|
|solubility||DMSO: >5 mg/mL|
Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50 = 11.6 μM.
|Precautionary statements||P264-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25|
|Safety Statements (Europe)||45|
|RIDADR||UN 2811 6.1/PG 2|
To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
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