|Related Categories||Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics,|
|solubility||H2O: soluble50 mg/mL|
|Gene Information||human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)|
Competitive muscarinic acetylcholine receptor antagonist.
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36/37/38|
|Safety Statements (Europe)||26-36|
Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Arima N, Uchida Y, Yu R, et al. Biochem. Biophys. Res. Commun. 435(3), 447-53, (2013)
Task demands dissociate the effects of muscarinic M1 receptor blockade and protein kinase C inhibition on attentional performance in rats. Robinson AM, Mangini DF, and Burk JA J. Psychopharmacol. 26(8), 1143-50, (2012)
A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil. Bartko SJ, Vendrell I, Saksida LM, et al. Psychopharmacology 214(2), 537-48, (2011)
Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury. Cox CD, West EJ, Liu MC, et al. J. Neurotrauma 25(11), 1355-65, (2008)
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy. Staroselsky A, Garcia-Bournissen F, and Koren G Gastroenterology 132(2), 824-5; author reply 825, (2007)
Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers. Kay GG and Wesnes KA BJU Int. 96(7), 1055-62, (2005)
Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task. Monteiro Moreira K, Lima Ferreira T, Vecchio Fornari R, et al. Brain Res. Bull. 67(6), 504-8, (2005)
Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies. Teaktong T, Piggott MA, Mckeith IG, et al. Behav. Brain Res. 161(2), 299-305, (2005)
Quantitative determination of pharmaceuticals using nano-electrospray ionization mass spectrometry after reversed phase mini-solid phase extraction. Qi L and Danielson ND J. Pharm. Biomed. Anal. 37(2), 225-30, (2005)
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