|Related Categories||Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
|recombinant||expressed in baculovirus infected Sf9 cells|
|form||buffered aqueous glycerol solution|
|mol wt||mol wt ~72 kDa|
|shipped in||dry ice|
|Gene Information||human ... EPHA3(2042)|
EPHA3 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. Analysis of human colorectal, breast, lung and pancreatic cancer samples shows somatic mutations in the EPHA3 gene. EPHA3 gene expression can be regulated by CD28 and IGF-1 in Jurkat cells and expression of EPHA3 is associated with adherence and motility of malignant T cells.
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
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