|Related Categories||Apoptosis Inducers, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience|
|biological source||from Gnomonia errabunda|
|solubility||DMSO: soluble10 mg/mL|
|ethanol: soluble10 mg/mL|
|methanol: soluble10 mg/mL|
Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).
Certificate of Analysis
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Wätjen, W., et al. Mol. Nutr. Food. Res. 53, 431-440, (2009)
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