|Related Categories||Autophagy, Autophagy Activators, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,|
|solubility||DMSO: soluble (~1 mg/ml)|
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
Certificate of Analysis
Certificate of Origin
Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
A major role for the Rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Iizuka, et al. Br. J. Pharmacol. 128, 925-933, (1999)
Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells Gonzalez-Robayna, I.J., et al. Mol. Endocrinol. 14, 1283-300, (2000)
Involvement of TRPV2 and SOCE in calcium influx disorder in DMD primary human myotubes with a specific contribution of α1-syntrophin and PLC/PKC in SOCE regulation. Harisseh R, Chatelier A, Magaud C, et al. Am. J. Physiol. Cell Physiol. 304(9), C881-94, (2013)
Involvement of basal and calcium-activated protein kinase C in neurotransmitter secretion in mouse motor synapses. Gaydukov AE, Marchenkova AA, and Balezina OP Bull. Exp. Biol. Med. 153(6), 820-3, (2012)
Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx. Jarrard RE, Wang Y, Salyer AE, et al. Mol. Pharmacol. 83(1), 191-205, (2013)
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Gan L, Guo K, Cremona ML, et al. Endocrinology 153(12), 5821-33, (2012)
Mechanical stretch reduces the effect of angiotensin II on potassium current in cardiac ventricular cells of adult Sprague Dawley rats. On the role of AT1 receptors as mechanosensors. De Mello WC J. Am. Soc. Hypertens. 6(6), 369-74, (2012)
EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Park YS and Cho NJ Mol. Cell Biochem. 370(1-2), 191-8, (2012)
6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line. Wang W, Song N, Zhang H, et al. Int. J. Biochem. Cell Biol. 44(11), 1987-92, (2012)
Estradiol acts directly and indirectly on multiple signaling pathways to phosphorylate cAMP-response element binding protein in GnRH neurons. Cheong RY, Kwakowsky A, Barad Z, et al. Endocrinology 153(8), 3792-803, (2012)
Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. Haines RJ, Corbin KD, Pendleton LC, et al. J. Biol. Chem. 287(31), 26168-76, (2012)
The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules. Sancho V, Nuche-Berenguer B, and Jensen RT Biochim. Biophys. Acta 1823(8), 1285-94, (2012)
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