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G2911 Sigma

GF 109203X

synthetic, ≥90% (HPLC)

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Synonym: 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I

GF 109203X synthetic, ≥90% (HPLC)
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Properties

Related Categories Autophagy, Autophagy Activators, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
biological source   synthetic
assay   ≥90% (HPLC)
solubility   DMSO: soluble (~1 mg/ml)
storage temp.   2-8°C

Description

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1

Quantity

For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Price and Availability

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