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G3798 Sigma

10074-G5

≥98% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine, N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine, N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine

  • CAS Number 413611-93-5

  • Empirical Formula (Hill Notation) C18H12N4O3

  • Molecular Weight 332.31

  •  MDL number MFCD00576774

10074-G5 ≥98% (HPLC)
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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience More...
assay   ≥98% (HPLC)
form   powder
color   red
solubility   DMSO: >10 mg/mL
storage temp.   room temp

Description

Biochem/physiol Actions

10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

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