HER4 (682-993), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
DOWNLOAD MSDS (PDF)Synonym: ERBB4, MG C138404, p180erbB4
-
Popular Documents: Datasheet (PDF)
Properties
| Related Categories | Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, |
| recombinant | expressed in baculovirus infected Sf9 cells |
| grade | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| activity | 569-770 nmol/min·mg |
| mol wt | mol wt ~57 kDa |
| shipped in | dry ice |
Description
Biochem/physiol Actions
HER4 or ERBB4 is a transmembrane receptor tyrosine kinase that belongs to epidermal growth factor receptor family. Through its interaction with its activating ligand heregulin, HER4 can regulate proliferation and differentiation of cells. HER4 ectodomain is cleaved by a metalloprotease, gamma-secretase that releases the HER4 intracellular domain from the membrane and facilitates its translocation to the nucleus. The kinase activity of HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells. Increased expression of HER4 has been detected in various cancers and this usually correlates to better survival.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
Price and Availability
Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Bulk Ordering & Pricing:
Need larger quantities for your development, manufacturing or research applications?
