|Related Categories||Alphabetical Index, Antibodies, Antibodies against Cytokines, Chemokines, and Growth Factors for Stem Cell Biology, Antibodies against Cytokines/Growth Factors/Chemokines for Stem Cell Biology, Antibodies for Cell Biology,|
|species reactivity||human, mouse, rat|
|application(s)||western blot: 0.5 μg/mL using human HeLa cell extract|
|antibody form||affinity isolated antibody|
|form||buffered aqueous solution|
|mol wt||antigen mol wt 66 kDa|
|shipped in||dry ice|
human ... IL1RAP(3556)|
mouse ... Il1rap(16180)
rat ... Il1rap(25466)
synthetic peptide corresponding to amino acids 525-540 of human Interleukin-1 Receptor Accessory Protein (Il-1RAcP). This sequence is identical in mouse and rat.
Interleukin-1 is a proinflammatory cytokine produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that exert their cellular effects by signaling through IL-1 receptor type 1 (IL-1R1). 1,2 IL-1 recruits Interleukin-1 Receptor Accessory Protein (IL-1RAcP) that stabilizes the ligand-receptor association. IL-1RAcP is expressed by astrocytes and neurons in the brain. IL-1RAcP does not regulate the responses of IL-1 directly but modulates the gene expression and inflammatory responses induced by IL-1.3,4 IL-1RAcP is critical in mediating the activation of IRAK and SAPK pathways by IL-1. Anti-Interleukin-1 Receptor Accessory Protein antibody recognizes human, mouse and rat IL-1RAcP (~66 kDa). There is no cross-reactivity to other members in the IL-1 and IL-18 receptor families.
Solution in phosphate buffered saline, containing 0.02% sodium azide.
Anti-Interleukin-1 Receptor Accessory Protein antibody is suitable for immunoblotting at a working concentration of 0.5 μg/ml using HeLa cell extract.
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Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
1. Interleukin-1, inflammasomes, autoinflammation and the skin Contassot E et al Swiss Med. Wkly. 142, w13590, (2010)
4. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases) Wesche H et al J. Biol. Chem. 272, 7727-31, (1997)
Greenfeder, S.A., et al. J. Biol. Chem. 270, 12757, (1995)
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