I8250 Sigma


Synonym: 3-Monoiodo-L-tyrosine

  • CAS Number 70-78-0

  • Linear Formula IC6H3-4-(OH)CH2CH(NH2)CO2H

  • Molecular Weight 307.09

  •  Beilstein Registry Number 2941266

  •  EC Number 200-744-8

  •  MDL number MFCD00002608

  •  PubChem Substance ID 24278154

  •  eCl@ss 32160406

  • Popular Documents:  FTNMR (PDF)  



Related Categories Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Neuroscience, Neurotransmission,
impurities   ~5% tyrosine
mp   210 °C (dec.)(lit.)
solubility   dilute aqueous acid: soluble
storage temp.   −20°C
Gene Information   human ... TH(7054)


Biochem/physiol Actions

Tyrosine hydroxylase inhibitor.


1, 5, 25 g in poly bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Customers Also Viewed

Safety & Documentation

Safety Information

WGK Germany 
Protocols & Articles
Peer-Reviewed Papers


Set your institution to view full text papers.

Influence of dopamine on GABA release in striatum: evidence for D1-D2 interactions and non-synaptic influences. Harsing, L.G., Jr., and Zigmond, M.J. Neuroscience 77, 419-429, (1997)


Steady-state kinetic mechanism of rat tyrosine hydroxylase. Fitzpatrick, P.F. Biochemistry 30, 3658-3662, (1991)


Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. Schutte RJ, Schutte SS, Algara J, et al. J. Neurophysiol. 112(4), 903-12, (2014)


Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium. Hamad ML, Engen W, Morris KR, et al. Pharm. Dev. Technol. 20(3), 314-9, (2015)


Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)


Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells. Sakamoto K, Hayashi A, Sakamoto A, Kiga D, et al. Nucleic Acids Res. 30, 4692-4699, (2002)


Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Müller EE, Locatelli V, Cella S, et al. Drugs 25(4), 399-432, (1983)


Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. Cheryl A Grice et al J. Med. Chem. 51, 4150-69, (2008)


Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)


Extrathyroidal physiology of monoiodotyrosine in humans. Tan SA, Lewis JE, Berk LS, et al. Clin. Physiol. Biochem. 8(3), 109-15, (1990)


The stimulation of human prolactin secretion by 3-Iodo-L-tyrosine. Smythe GA, Compton PJ, and Lazarus L J. Clin. Endocrinol. Metab. 40(4), 714-6, (1975)


Interference of iodine-125 ligands in radioimmunoassay: evidence implicating thyroxine-binding globulin. Painter K and Vader CR Clin. Chem. 25(5), 797-9, (1979)


A variant of iodotyrosine-dehalogenase deficiency. Ismail-Beigi F and Rahimifar M J. Clin. Endocrinol. Metab. 44(3), 499-506, (1977)


Aromatic amino acids and their derivatives as ligands for the isolation of aspartic proteinases. Kucerová Z and Tichá M J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 770(1-2), 121-8, (2002)


Merck 14,5047

Beil. 14,IV,2369

FT-IR 1 (2), 256:C / FT-IR 2 (2), 2752:A / FT-NMR 1 (2), 1189:B / IR-Spectra (3), 998:D / IR-Spectra (2), 874:A / NMR-Reference 2 (2), 258:D / RegBook 1 (2), 1847:D / Sigma FT-IR 1 (1), 191:B / Structure Index 1, 296:A:4

Related Products

related product

Product #


Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?