K-252a Ready Made Solution, from Nonomuraea longicatena, >98%

Properties

Related Categories	Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Protein Kinase A, C, and G (PKA, PKC, PKG), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors More...
biological source	from Nonomuraea longicatena
assay	>98%
shipped in	dry ice
storage temp.	−20°C
Gene Information	human ... NTRK1(4914) rat ... Prkca(24680)

Description

Physical form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Biochem/physiol Actions

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.¹ At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.² K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.³ K-252a improves psoriasis in a SCID mouse-human skin model⁴ and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.⁵

Price and Availability

Related Papers

1. Ecto-protein kinase and surface protein phosphorylation in PC12 cells: interactions with nerve growth factor. Pawlowska, Z., et al. J. Neurochem. 60, 678-686, (1993)

Documents

Certificate of Analysis

K2015 - Datasheet (101KB)

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
WGK Germany	1
Flash Point(F)	188.6 °F
Flash Point(C)	87 °C