|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology,|
|biological source||from Nonomuraea longicatena|
|shipped in||dry ice|
human ... NTRK1(4914)|
rat ... Prkca(24680)
Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.1 At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.2 K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.3 K-252a improves psoriasis in a SCID mouse-human skin model4 and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.5
Certificate of Analysis
|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
|RIDADR||UN 1993 / PGIII|
|Flash Point(F)||188.6 °F|
|Flash Point(C)||87 °C|
4. K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. Raychaudhuri, S.P., et al. J. Invest. Dermatol. 122, 812-819, (2004)
5. Winston, J.H., et al. Pain 4, 329-337, (2003)
Inhibition of actin-myosin-ATP interaction of smooth muscle native actomyosin is not closely associated with inhibition of its myosin light chain phosphorylation: studies with derivatives of antibiotic SF-2370. Kohama K, Takano-Ohmuro H, Sohda M, et al. Prog. Clin. Biol. Res. 315, 460-2, (1989)
Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor. Haridas B Rode et al Bioorg. Med. Chem. 19, 429-39, (2011)
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