|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,|
|drug control||USDEA Schedule III; stupéfiant; regulated under CDSA - not available from Sigma-Aldrich Canada|
|solubility||H2O: soluble200 mg/mL|
Selective NMDA glutamate receptor antagonist; veterinary anesthetic.
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Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36/37/38|
|Safety Statements (Europe)||26|
The ion channel family of glutamate receptors (“ionotropic” glutamate receptors or iGluR) comprises three major subtypes based on pharmacology and protein structure.
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver. Schobel SA, Chaudhury NH, Khan UA, et al. Neuron 78(1), 81-93, (2013)
Brief report: perioperative analgesic efficacy and plasma concentrations of S+ -ketamine in continuous epidural infusion during thoracic surgery. Feltracco P, Barbieri S, Rizzi S, et al. Anesth. Analg. 116(6), 1371-5, (2013)
Prior determination of baseline minimum alveolar concentration (MAC) of isoflurane does not influence the effect of ketamine on MAC in rabbits. Gianotti G, Valverde A, Sinclair M, et al. Can. J. Vet. Res. 76(4), 261-7, (2012)
Pharmacological inhibition of p38 mitogen-activated protein kinases affects KC/CXCL1-induced intraluminal crawling, transendothelial migration, and chemotaxis of neutrophils in vivo. Xu N, Hossain M, and Liu L Mediators Inflamm. 2013, 290565, (2013)
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt. Lacoh CM, Bodogan T, Kaila K, et al. Br. J. Anaesth. 110 Suppl 1, i10-8, (2013)
Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. Poterucha TJ, Weiss WT, Warndahl RA, et al. Journal. of. Drugs in. Dermatology. 12(3), 308-10, (2013)
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