|Related Categories||Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,|
|Gene Information||human ... DRD2(1813), DRD4(1815), HTR2A(3356), HTR2B(3357), HTR7(3363)|
D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.
Combination of clonidine sedation and spontaneous breathing-pressure support upon acute respiratory distress syndrome: a feasibility study in four patients. Pichot C, Picoche A, Saboya-Steinbach MI, et al. Acta Anaesthesiol. Belg. 63(3), 127-33, (2012)
[RÉALITÉ LT, a pharmacoepidemiological study of semiology and therapeutic strategy of patients with schizophrenia treated by antipsychotic loxapine in routine clinical practice]. Cousin FR, Samuelian JC, Saoud M, et al. Encephale 38(1), 64-74, (2012)
Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Kwentus J, Riesenberg RA, Marandi M, et al. Bipolar Disord. 14(1), 31-40, (2012)
Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder. Citrome L Int. J. Clin. Pract. 66(3), 318-25, (2012)
Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS. Wong YC, Wo SK, and Zuo Z J. Pharm. Biomed. Anal. 58, 83-93, (2012)
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal. Eiden C, Capdevielle D, Deddouche C, et al. J. Addict. Med. 5(4), 302-3, (2011)
Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. Allen MH, Feifel D, Lesem MD, et al. J. Clin. Psychiatry 72(10), 1313-21, (2011)
Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Lesem MD, Tran-Johnson TK, Riesenberg RA, et al. Br. J. Psychiatry 198(1), 51-8, (2011)
Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma. Zimmer JS, Needham SR, Christianson CD, et al. Bioanalysis 2(12), 1989-2000, (2010)
"Extended" antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial. Remington G, Seeman P, Feingold A, et al. J. Clin. Psychiatry 72(8), 1042-8, (2011)
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